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Literature DB >> 7036347

Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys.

Abstract

Oscillations in the concentration of plasma glucose were found to reflect large fluctuations in hepatic glucose production. The fluctuations in glucose production were synchronous with fluctuations in the concentration of plasma insulin and glucagon. This synchrony suggests that hepatic pathways are entrained to the islet cycle with a minimal time delay.

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Year: 1982 PMID： 7036347 DOI： 10.1126/science.7036347

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

9 in total

1. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo.

Authors: L Getty; A E Panteleon; S D Mittelman; M K Dea; R N Bergman
Journal: J Clin Invest Date: 2000-08 Impact factor: 14.808

2. Low- and high-frequency insulin secretion pulses in normal subjects and pancreas transplant recipients: role of extrinsic innervation.

Authors: G E Sonnenberg; R G Hoffmann; C P Johnson; A H Kissebah
Journal: J Clin Invest Date: 1992-08 Impact factor: 14.808

Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys.

1. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo.

2. Low- and high-frequency insulin secretion pulses in normal subjects and pancreas transplant recipients: role of extrinsic innervation.

3. Negative feedback synchronizes islets of Langerhans.

Review 4. Pulsatility of insulin and glucagon release: physiological significance and pharmacological implications.

5. Intra- and inter-islet synchronization of metabolically driven insulin secretion.

6. Complex patterns of metabolic and Ca²⁺ entrainment in pancreatic islets by oscillatory glucose.

7. Measurement of the entrainment window of islets of Langerhans by microfluidic delivery of a chirped glucose waveform.

8. A Unifying Organ Model of Pancreatic Insulin Secretion.

9. Temperature as a Circadian Marker in Older Human Subjects: Relationship to Metabolic Syndrome and Diabetes.