Literature DB >> 7035426

Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger.

H P Fiedler, W Wörner, H Zähner, H P Kaiser, W Keller-Schierlein, A Müller.   

Abstract

Fermentations of Streptomyces violaceoniger TU 905 produce the antifungal antibiotics niphithricins A, B, elaiophylin and nigericin. The niphithricins have been characterized as new macrolide antibiotics, and the previously unknown structure of elaiophylin was determined to be a macrodiolide. The niphithricins were biologically active against Gram-positive bacteria and fungi. The mode of action is attributed to an alteration of the membrane permeability.

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Year:  1981        PMID： 7035426     DOI： 10.7164/antibiotics.34.1107

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species.

Authors:  Liping Gong; Yi Xiao; Qiang Liu; Sumei Li; Changsheng Zhang; Jinsong Liu
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-12-23

2.  Biotechnological preparation of the elaiophylin.

Authors:  M Cikosová; M Blazsek; M Kubis; J Gajdosíková; G Borosová
Journal:  Folia Microbiol (Praha)       Date:  2004       Impact factor: 2.099

3.  Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

Authors:  Xuejiao Zhao; Yong Fang; Yang Yang; Yu Qin; Peng Wu; Ting Wang; Huiling Lai; Li Meng; Daowen Wang; Zhihui Zheng; Xinhua Lu; Hua Zhang; Qinglei Gao; Jianfeng Zhou; Ding Ma
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

Review 4.  Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-03       Impact factor: 1.880

5.  Macrodiolide formation by the thioesterase of a modular polyketide synthase.

Authors:  Yongjun Zhou; Patrícia Prediger; Luiz Carlos Dias; Annabel C Murphy; Peter F Leadlay
Journal:  Angew Chem Int Ed Engl       Date:  2015-03-06       Impact factor: 15.336

6.  Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products.

Authors:  Doralyn S Dalisay; David E Williams; Xiao Ling Wang; Ryan Centko; Jessie Chen; Raymond J Andersen
Journal:  PLoS One       Date:  2013-10-10       Impact factor: 3.240

7.  Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis.

Authors:  Haet Nim Lim; Jun-Pil Jang; Jang Mi Han; Jae-Hyuk Jang; Jong Seog Ahn; Hye Jin Jung
Journal:  Molecules       Date:  2018-03-02       Impact factor: 4.411

Review 8.  Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship.

Authors:  Xiaoyuan Song; Ganjun Yuan; Peibo Li; Sheng Cao
Journal:  Molecules       Date:  2019-10-30       Impact factor: 4.411

9.  Elaiophylin Inhibits Tumorigenesis of Human Uveal Melanoma by Suppressing Mitophagy and Inducing Oxidative Stress via Modulating SIRT1/FoxO3a Signaling.

Authors:  Xue Zhu; Wenjun Zou; Xinmin Meng; Jiali Ji; Xun Wang; Hong Shu; Yuan Chen; Donghui Pan; Ke Wang; Fanfan Zhou
Journal:  Front Oncol       Date:  2022-03-21       Impact factor: 6.244

10.  Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase.

Authors:  Yongjun Zhou; Patrícia Prediger; Luiz Carlos Dias; Annabel C Murphy; Peter F Leadlay
Journal:  Angew Chem Weinheim Bergstr Ger       Date:  2015-03-06
  10 in total

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