Literature DB >> 7035362

Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.

L A Chedid, M A Parant, F M Audibert, G J Riveau, F J Parant, E Lederer, J P Choay, P L Lefrancier.   

Abstract

Immunostimulant activities of muramyl dipeptide (enhancement of specific immune responses and of nonspecific resistance to infection) were retained by its N-acetylmuramyl-L-alanyl-D-glutaminyl-n-butyl ester derivative, although very large amounts administered intravenously, or even by the very sensitive intracerebroventricular route, did not elicit fever in the rabbit. This analog also appeared to be devoid of other secondary effects which have been observed after administration of muramyl dipeptide.

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Year:  1982        PMID： 7035362      PMCID： PMC351055          DOI： 10.1128/iai.35.2.417-424.1982

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Modulation of the immune response by a synthetic adjuvant and analogs.

Authors:  L Chedid; F Audibert; P Lefrancier; J Choay; E Lederer
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

2.  Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components.

Authors:  F Audibert; L Chédid; P Lefrancier; J Choay
Journal:  Cell Immunol       Date:  1976-02       Impact factor: 4.868

3.  Correlation of stereochemically specific structure in muramyl dipeptide between macrophage activation and adjuvant activity.

Authors:  A Tanaka; S Nagao; R Saito; S Kotani; S Kusumoto; T Shiba
Journal:  Biochem Biophys Res Commun       Date:  1977-07-25       Impact factor: 3.575

4.  Gelation of the amoebocyte lysate of Tachypleus tridentatus by cell wall digest of several gram-positive bacteria and synthetic peptidoglycan subunits of natural and unnatural configurations.

Authors:  S Kotani; Y Watanabe; F Kinoshita; K Kato; K Harada
Journal:  Biken J       Date:  1977-03

5.  Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.

Authors:  F Ellouz; A Adam; R Ciorbaru; E Lederer
Journal:  Biochem Biophys Res Commun       Date:  1974-08-19       Impact factor: 3.575

6.  An immunological study of the diphtheria toxin molecule.

Authors:  A M Pappenheimer; T Uchida; A A Harper
Journal:  Immunochemistry       Date:  1972-09

7.  Dirunal variations in rabbits: hematological parameters.

Authors:  R R Fox; C W Laird
Journal:  Am J Physiol       Date:  1970-06

8.  Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.

Authors:  S Kotani; Y Watanabe; T Shimono; K Harada; T Shiba
Journal:  Biken J       Date:  1976-03

9.  Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.

Authors:  L Chedid; M Parant; F Parant; P Lefrancher; J Choay; E Lederer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

10.  Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.

Authors:  S Kotani; Y Watanabe; F Kinoshita; T Shimono; I Morisaki
Journal:  Biken J       Date:  1975-06
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  51 in total

1.  The synthetic immunomodulator murabutide controls human immunodeficiency virus type 1 replication at multiple levels in macrophages and dendritic cells.

Authors:  E C Darcissac; M J Truong; J Dewulf; Y Mouton; A Capron; G M Bahr
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Involvement of gamma interferon in antibody enhancement by adjuvants.

Authors:  M J Odean; C M Frane; M Van derVieren; M A Tomai; A G Johnson
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441

3.  Selective regulation of human immunodeficiency virus-infected CD4(+) lymphocytes by a synthetic immunomodulator leads to potent virus suppression in vitro and in hu-PBL-SCID mice.

Authors:  G M Bahr; E C Darcissac; N Castéran; C Amiel; C Cocude; M J Truong; J Dewulf; A Capron; Y Mouton
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

4.  Adjuvants et stimulants de l'immunité: propriétés immunorégulatrices du muramyl-dipeptide, des corynébactéries anaérobies et du diéthyldithiocarbamate de sodium.

Authors:  D Archambault; G Morin
Journal:  Can Vet J       Date:  1988-01       Impact factor: 1.008

Review 5.  Unleashing the therapeutic potential of NOD-like receptors.

Authors:  Kaoru Geddes; João G Magalhães; Stephen E Girardin
Journal:  Nat Rev Drug Discov       Date:  2009-06       Impact factor: 84.694

6.  Effect of muramyl peptides on mitochondrial respiration.

Authors:  N El-Jamal; G M Bahr; K S Echtay
Journal:  Clin Exp Immunol       Date:  2009-01       Impact factor: 4.330

7.  Stimulation of non-specific resistance to infections by synthetic immunoregulatory agents.

Authors:  M Parant; L Chedid
Journal:  Infection       Date:  1985       Impact factor: 3.553

8.  Depressed chemiluminescence response by influenza virus is enhanced after conjugation of viral subunits to muramyl dipeptide.

Authors:  K N Masihi; W Lange; B Rohde-Schulz; L Chedid; M Jolivet
Journal:  Infect Immun       Date:  1985-10       Impact factor: 3.441

9.  Stimulation of non-specific resistance to infections by synthetic immunoregulatory agents.

Authors:  M Parant; L Chedid
Journal:  Infection       Date:  1984 May-Jun       Impact factor: 3.553

10.  Successful immunization with a totally synthetic diphtheria vaccine.

Authors:  F Audibert; M Jolivet; L Chedid; R Arnon; M Sela
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205
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