Literature DB >> 7034716

Proline biosynthesis in Escherichia coli. Stoichiometry and end-product identification of the reaction catalysed by glutamate semialdehyde dehydrogenase.

D J Hayzer, T Leisinger.   

Abstract

The stoichiometry of the oxidative phosphorylation of glutamic acid 5-semialdehyde by gamma-glutamyl phosphate reductase (glutamate semialdehyde dehydrogenase) has been established. Equimolar amounts of NADP+ and L-glutamic acid 5-semialdehyde are consumed and equimolar amounts of 5-oxiopyrroilidine-2-carboxylic acid and NADPH are formed. The end-product of the reaction is demonstrated to be 5-oxopyrrolidine-2-carboxylic acid, probably arising from the true end-product gamma-glutamyl phosphate.

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Year:  1981        PMID： 7034716      PMCID： PMC1163123          DOI： 10.1042/bj1970269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Mechanism of glutamic acid activation and glutamine synthesis.

Authors:  A MEISTER; P R KRISHNASWAMY; V PAMILJANS
Journal:  Fed Proc       Date:  1962 Nov-Dec

2.  Transfer of oxygen in the glutamine synthetase reaction.

Authors:  A KOWALSKY; C WYTTENBACH; L LANGER; D E KOSHLAND
Journal:  J Biol Chem       Date:  1956-04       Impact factor: 5.157

3.  Improved chemical synthesis and enzymatic assay of delta-1-pyrroline-5-carboxylic acid.

Authors:  I Williams; L Frank
Journal:  Anal Biochem       Date:  1975-03       Impact factor: 3.365

4.  Energetics of peptide formation.

Authors:  J W BREITENBACH; J DERKOSCH; F WESSELY
Journal:  Nature       Date:  1952-05-31       Impact factor: 49.962

5.  Properties and analysis of a stable derivative of pyrroline-5-carboxylic acid for use in metabolic studies.

Authors:  V A Mezl; W E Knox
Journal:  Anal Biochem       Date:  1976-08       Impact factor: 3.365

6.  The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway.

Authors:  A Baich
Journal:  Biochim Biophys Acta       Date:  1971-07-20

7.  Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase.

Authors:  A Baich
Journal:  Biochim Biophys Acta       Date:  1969-12-30

8.  ENZYMATIC SYNTHESIS OF BETA-AMINOGLUTARAMIC ACID (BETA-GLUTAMINE) BY GLUTAMINE SYNTHETASE: EVIDENCE FOR THE UTILIZATION OF BETA-AMINOGLUTARYLPHOSPHATE.

Authors:  E KHEDOURI; V P WELLNER; A MEISTER
Journal:  Biochemistry       Date:  1964-06       Impact factor: 3.162
  8 in total
  6 in total

1.  Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae.

Authors:  D M Tomenchok; M C Brandriss
Journal:  J Bacteriol       Date:  1987-12       Impact factor: 3.490

2.  Proline accumulation in developing grapevine fruit occurs independently of changes in the levels of delta1-pyrroline-5-carboxylate synthetase mRNA or protein.

Authors:  A P Stines; D J Naylor; P B Høj; R van Heeswijck
Journal:  Plant Physiol       Date:  1999-07       Impact factor: 8.340

3.  Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection.

Authors:  R D Sleator; C G Gahan; C Hill
Journal:  Appl Environ Microbiol       Date:  2001-06       Impact factor: 4.792

4.  Development of a 3-hydroxypropionate resistant Escherichia coli strain.

Authors:  Min Liu; Xueping Han; Mo Xian; Yamei Ding; Huizhou Liu; Guang Zhao
Journal:  Bioengineered       Date:  2015-12-28       Impact factor: 3.269

5.  Purification and characteristics of a gamma-glutamyl kinase involved in Escherichia coli proline biosynthesis.

Authors:  C J Smith; A H Deutch; K E Rushlow
Journal:  J Bacteriol       Date:  1984-02       Impact factor: 3.490

6.  Genetic analysis of the proBA genes of Salmonella typhimurium: physical and genetic analyses of the cloned proB+ A+ genes of Escherichia coli and of a mutant allele that confers proline overproduction and enhanced osmotolerance.

Authors:  M J Mahan; L N Csonka
Journal:  J Bacteriol       Date:  1983-12       Impact factor: 3.490
  6 in total

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