Literature DB >> 7032505

The specificity of macrophage elastase on the insulin B-chain.

C Kettner, E Shaw, R White, A Janoff.   

Abstract

The specificity of macrophage elastase obtained from mouse peritoneal exudative macrophages was determined in the hydrolysis of the oxidized insulin B-chain. This elastase hydrolysed two bonds, namely Ala-Leu and Tyr-Leu. The rate of hydrolysis of the latter was two to three times greater than that of the former. The hexapeptide Glu-Ala-Leu-Tyr-Leu-Val, obtained by cleavage of the insulin B-chain, was not hydrolysed by macrophage elastase. When EDTA was present, proteolysis of the B-chain was not observed. The macrophage elastase is therefore different from the neutrophil elastase in specificity and mechanism.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7032505      PMCID： PMC1162899          DOI： 10.1042/bj1950369

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Effects of elastase, collagenase, and papain on structure and function of rat lungs in vitro.

Authors:  W G Johanson; A K Pierce
Journal:  J Clin Invest       Date:  1972-02       Impact factor: 14.808

2.  Fenestrae in the alveolar membrane of the human lung.

Authors:  K K Pump
Journal:  Chest       Date:  1974-04       Impact factor: 9.410

3.  The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum.

Authors:  P D Kaplan; C Kuhn; J A Pierce
Journal:  J Lab Clin Med       Date:  1973-09

4.  Further studies of human alveolar macrophage alanine-P-nitrophenyl esterase. Evidence of resistance to endogenous antiproteases.

Authors:  R Rosenberg; R Sandhaus; A Janoff
Journal:  Am Rev Respir Dis       Date:  1972-07

5.  The specificity of purified porcine pancreatic elastase.

Authors:  A S Narayanan; R A Anwar
Journal:  Biochem J       Date:  1969-08       Impact factor: 3.857

6.  Experimental emphysema in rats: elastolytic titer of inducing enzyme as determinant of the response.

Authors:  C E Blackwood; Y Hosannah; E Perman; S Keller; I Mandl
Journal:  Proc Soc Exp Biol Med       Date:  1973-11

7.  Inhibition of human granulocyte elastase by serum alpha-1-antitrypsin.

Authors:  A Janoff
Journal:  Am Rev Respir Dis       Date:  1972-01

8.  On the size of the active site in proteases. I. Papain.

Authors:  I Schechter; A Berger
Journal:  Biochem Biophys Res Commun       Date:  1967-04-20       Impact factor: 3.575

9.  Partial purification and characterization of mouse peritoneal exudative macrophage elastase.

Authors:  R R White; D Norby; A Janoff; R Dearing
Journal:  Biochim Biophys Acta       Date:  1980-03-14

10.  Elastase secretion by stimulated macrophages. Characterization and regulation.

Authors:  Z Werb; S Gordon
Journal:  J Exp Med       Date:  1975-08-01       Impact factor: 14.307
View more
  4 in total

Review 1.  MMPs and TIMPs--an historical perspective.

Authors:  J Frederick Woessner
Journal:  Mol Biotechnol       Date:  2002-09       Impact factor: 2.695

2.  Interaction of mouse macrophage elastase with native and oxidized human alpha 1-proteinase inhibitor.

Authors:  M J Banda; E J Clark; S Sinha; J Travis
Journal:  J Clin Invest       Date:  1987-05       Impact factor: 14.808

3.  Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency.

Authors:  J I Weitz; S L Landman; K A Crowley; S Birken; F J Morgan
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

4.  MMP12 knockout prevents weight and muscle loss in tumor-bearing mice.

Authors:  Lingbi Jiang; Mingming Yang; Shihui He; Zhengyang Li; Haobin Li; Ting Niu; Dehuan Xie; Yan Mei; Xiaodong He; Lili Wei; Pinzhu Huang; Mingzhe Huang; Rongxin Zhang; Lijing Wang; Jiangchao Li
Journal:  BMC Cancer       Date:  2021-12-04       Impact factor: 4.430
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.