Literature DB >> 7030465

Treatment of acetaminophen poisoning.

E M Sellers, F Freedman.   

Abstract

Acetaminophen is an analgesic that is frequently used in Canada, and the occurrence of overdoses with this drug seems to be increasing. The most serious complication of acetaminophen overdose is hepatic failure. Because of pathophysiologic effects of acetaminophen poisoning and the mechanisms of its toxic effects are now better understood, a rational approach to treatment is possible. Several precursors of glutathione, acetylcysteine in particular, are effective in preventing liver damage if administered within 10 hours of acetaminophen ingestion. Plasma acetaminophen levels are a helpful guide to therapy.

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Year:  1981        PMID： 7030465      PMCID： PMC1862716     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  11 in total

1.  Controlled trial of cysteamine and dimercaprol after paracetamol overdose.

Authors:  R D Hughes; B G Gazzard; M A Hanid; P N Trewby; I M Murray-Lyon; M Davis; R Williams; J R Bennet
Journal:  Br Med J       Date:  1977-11-26

2.  Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.

Authors:  J R Mitchell; S S Thorgeirsson; W Z Potter; D J Jollow; H Keiser
Journal:  Clin Pharmacol Ther       Date:  1974-10       Impact factor: 6.875

3.  Treatment of acute paracetamol poisoning.

Authors:  D Maclean; T J Peters; R A Brown; M McCathie; G F Baines; P G Robertson
Journal:  Lancet       Date:  1968-10-19       Impact factor: 79.321

4.  Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine.

Authors:  J S Burks; J E Walker; B H Rumack; J E Ott
Journal:  JAMA       Date:  1974-12-04       Impact factor: 56.272

5.  Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

Authors:  J R Mitchell; D J Jollow; W Z Potter; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

6.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

Authors:  J R Mitchell; D J Jollow; W Z Potter; D C Davis; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

7.  Drug therapy. Acetaminophen.

Authors:  J Koch-Weser
Journal:  N Engl J Med       Date:  1976-12-02       Impact factor: 91.245

8.  Late treatment of paracetamol poisoning with mercaptamine.

Authors:  J M Smith; W O Roberts; S M Hall; T A White; A A Gilbertson
Journal:  Br Med J       Date:  1978-02-11

9.  Changing pattern of drugs used for self-poisoning.

Authors:  A T Proudfoot; J Park
Journal:  Br Med J       Date:  1978-01-14

10.  The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage.

Authors:  L F Prescott
Journal:  Health Bull (Edinb)       Date:  1978-07
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  5 in total

Review 1.  Liver enzyme alteration: a guide for clinicians.

Authors:  Edoardo G Giannini; Roberto Testa; Vincenzo Savarino
Journal:  CMAJ       Date:  2005-02-01       Impact factor: 8.262

2.  Microcomputers in medicine.

Authors:  G Piasecki
Journal:  Can Med Assoc J       Date:  1982-06-01       Impact factor: 8.262

3.  Treatment of acetaminophen poisoning.

Authors:  M Nasadi
Journal:  Can Med Assoc J       Date:  1982-02-01       Impact factor: 8.262

4.  Acetaminophen: a practical pharmacologic overview.

Authors:  C H Jackson; N C MacDonald; J W Cornett
Journal:  Can Med Assoc J       Date:  1984-07-01       Impact factor: 8.262

Review 5.  Elevated Liver Enzymes in Asymptomatic Patients - What Should I Do?

Authors:  Mazyar Malakouti; Archish Kataria; Sayed K Ali; Steven Schenker
Journal:  J Clin Transl Hepatol       Date:  2017-09-21
  5 in total

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