Literature DB >> 70295

Monoclonal IgG3-kappa and IgG1-lambda proteins with different idiotypic determinants present in a single patient.

S Sarasombath, J Mestecky, F Skvaril.   

Abstract

Two monoclonal proteins belonging to IgG3-kappa and IgG1-lambda subclasses were detected in a single patient. Immunochemical analysis revealed that the idiotypic determinants of the two proteins were different. Examination of bone marrow by an immunofluorescence technique indicated that these two proteins were produced in different cells, although both kappa and lambda chains were present in a minute proportion of the cells. J chain was present in all cells that produced IgG.

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Year:  1977        PMID： 70295      PMCID： PMC1541030     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

1.  THE OCCURRENCE OF BENIGN, ESSENTIAL MONOCLONAL (M TYPE), NON-MACROMOLECULAR HYPERGLOBULINEMIA AND ITS DIFFERENTIAL DIAGNOSIS. IV. STUDIES IN THE GAMMAPATHIES.

Authors:  J WALDENSTROEM
Journal:  Acta Med Scand       Date:  1964-09

2.  Site of J chain attachment to human polymeric IgA.

Authors:  J Mestecky; R E Schrohenloher; R Kulhavy; G P Wright; M Tomana
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205

3.  Double myeloma. Production of both IgG type lambda and IgA type lambda myeloma proteins by a single plasma cell line.

Authors:  R A Rudders; V Yakulis; P Heller
Journal:  Am J Med       Date:  1973-08       Impact factor: 4.965

4.  Monoclonal IgA and IgM in the serum of a single patient (SC). I. Sharing of individually specific determinants between IgA and IgM.

Authors:  Y Yagi; D Pressman
Journal:  J Immunol       Date:  1973-02       Impact factor: 5.422

5.  Monoclonal IgA and IgM in the serum of a single patient (SC). 3. Immunofluorescent identification of cells producing IgA and IgM.

Authors:  A Y Silverman; Y Yagi; D Pressman; R R Ellison; D C Tormey
Journal:  J Immunol       Date:  1973-02       Impact factor: 5.422

6.  Immunohistochemical localization of amylase, lysozyme and immunoglobulins in the human parotid gland.

Authors:  F W Kraus; J Mestecky
Journal:  Arch Oral Biol       Date:  1971-07       Impact factor: 2.633

7.  Comparative studies on monotypic IgMlamba and IgGkappa from an individual patient. II. Amino-terminal sequence analyses.

Authors:  J E Hopper; C Noyes; R Heinrikson; J W Kessel
Journal:  J Immunol       Date:  1976-03       Impact factor: 5.422

8.  Sharing of individual antigenic determinants between a gamma G and a gamma M protein in the same myeloma serum.

Authors:  G M Penn; H G Kunkel; H M Grey
Journal:  Proc Soc Exp Biol Med       Date:  1970-12

9.  Antibody differentiation: apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins.

Authors:  C Sledge; D S Fair; B Black; R G Krueger; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

10.  Parallel synthesis of immunoglobulins and J chain in pokeweed mitogen-stimulated normal cells and in lymphoblastoid cell lines.

Authors:  J Mestecky; R J Winchester; T Hoffman; H G Kunkel
Journal:  J Exp Med       Date:  1977-03-01       Impact factor: 14.307
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  3 in total

1.  Deleted IgG1 and IgG2 H chains in a patient with an IgG subclass imbalance.

Authors:  J P Lebreton; M Fontaine; J Rousseaux; P Youinou; D Hurez; L Rivat-Peran; J P Bernards
Journal:  Clin Exp Immunol       Date:  1982-01       Impact factor: 4.330

2.  Presence of J chain in human lymphoid cells.

Authors:  J Mestecky; J L Preud'homme; S S Crago; E Mihaesco; J T Prchal; A J Okos
Journal:  Clin Exp Immunol       Date:  1980-02       Impact factor: 4.330

3.  Myeloma with immunohistochemically different cell populations: implication for the validity of immunohistochemical assessment of lymphoma cell monoclonality.

Authors:  K Metz; L D Leder
Journal:  Klin Wochenschr       Date:  1980-04-15
  3 in total

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