Literature DB >> 7028794

A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide.

J E Peachey, J F Brien, C A Roach, C W Loomis.   

Abstract

Disulfiram and calcium carbimide are widely used alcohol deterrents. Their safe use, however, requires a knowledge of their pharmacology, toxicity, and interactions with alcohol and other drugs. The absorption, metabolism, and elimination of these compounds are described, and elimination of these compounds are described, as is the mechanism of their reaction with ethanol. The effects and limitations of the interaction between ethanol and disulfiram and calcium carbimide are discussed. Four areas of concern regarding toxicity are discussed, including medical complications of the reactions with alcohol, toxicity associated with repeated doses of disulfiram or calcium carbimide, possible interactions with other drugs, and acetaldehyde-induce hepatotoxicity and cardiotoxicity.

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Year:  1981        PMID： 7028794     DOI： 10.1097/00004714-198101000-00005

Source DB:  PubMed          Journal:  J Clin Psychopharmacol        ISSN： 0271-0749            Impact factor:   3.153


  9 in total

1.  Catatonic reaction to omeprazole and disulfiram in a patient with alcohol dependence.

Authors:  R Hajela; G M Cunningham; B M Kapur; J E Peachey; P Devenyi
Journal:  CMAJ       Date:  1990-12-01       Impact factor: 8.262

2.  Concentration-time profiles of ethanol and acetaldehyde in human volunteers treated with the alcohol-sensitizing drug, calcium carbimide.

Authors:  A W Jones; J Neiman; M Hillbom
Journal:  Br J Clin Pharmacol       Date:  1988-02       Impact factor: 4.335

3.  Interaction of disulfiram with antiretroviral medications: efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism.

Authors:  Elinore F McCance-Katz; Valerie A Gruber; George Beatty; Paula Lum; Qing Ma; Robin DiFrancesco; Jill Hochreiter; Paul K Wallace; Morris D Faiman; Gene D Morse
Journal:  Am J Addict       Date:  2013-10-11

4.  Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.

Authors:  Sulggi A Lee; Julian H Elliott; James McMahon; Wendy Hartogenesis; Namandje N Bumpus; Jeffrey D Lifson; Robert J Gorelick; Peter Bacchetti; Steven G Deeks; Sharon R Lewin; Radojka M Savic
Journal:  Clin Pharmacol Ther       Date:  2018-10-09       Impact factor: 6.875

5.  Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?

Authors:  Carmen Verge; M Isabel Lucena; Enrique López-Torres; M José Puche-Garcia; Enrique Fraga; Manuel Romero-Gomez; Raúl J Andrade
Journal:  World J Gastroenterol       Date:  2006-08-21       Impact factor: 5.742

Review 6.  The role of drugs in the treatment of alcoholism.

Authors:  J E Peachey; C A Naranjo
Journal:  Drugs       Date:  1984-02       Impact factor: 9.546

Review 7.  Clinical pathology of alcohol.

Authors:  V Marks
Journal:  J Clin Pathol       Date:  1983-04       Impact factor: 3.411

8.  Disulfiram-induced reversible hypertension: a prospective case series and review of the literature.

Authors:  Ranganath R Kulkarni; Santosh I Ramdurg; Bhavya K Bairy
Journal:  Indian J Psychol Med       Date:  2014-10

9.  Disulfiram induced reversible hypertension: a prospective case study and brief review.

Authors:  Ranganath R Kulkarni; Bhavya K Bairy
Journal:  Indian J Psychol Med       Date:  2013-04
  9 in total

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