Literature DB >> 7025752

Inhibition of aminoglycoside activity in heparin.

L Nilsson, R Maller, S Anséhn.   

Abstract

Measurements of aminoglycosides by an agar disk diffusion assay are inhibited by heparin in a dose-dependent way. When assayed by a homogeneous immunoassay, this was only evident for tobramycin. This indicates that specimens for aminoglycoside measurement should not be obtained in heparinized tubes. When heparin is used clinically as an anticoagulant, the amount in blood does not reach levels that affect the aminoglycoside activity.

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Year:  1981        PMID： 7025752      PMCID： PMC181656          DOI： 10.1128/AAC.20.2.155

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  The elimination from plasma of intravenous heparin. An experimental study on dogs and humans.

Authors:  P OLSSON; H LAGERGREN; S EK
Journal:  Acta Med Scand       Date:  1963-05

2.  Simple method for elimination of aminoglycosides from serum to permit bioassay of other antimicrobial agents.

Authors:  P Stevens; L S Young
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

3.  New rapid bioassay of gentamicin based on luciferase assay of extracellular ATP in bacterial cultures.

Authors:  L Nilsson
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

Review 4.  Heparin therapy and its laboratory control.

Authors:  W R Pitney
Journal:  Br J Haematol       Date:  1970-05       Impact factor: 6.998

5.  Factors affecting gentamicin assay.

Authors:  L Nilsson
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191

6.  Inhibitory effect of heparin on gentamicin concentrations in blood.

Authors:  C Regamey; D Schaberg; W M Kirby
Journal:  Antimicrob Agents Chemother       Date:  1972-04       Impact factor: 5.191

7.  A rapid semiautomated bioassay of gentamicin based on luciferase assay of bacterial adenosine triphosphate.

Authors:  L Nilsson; H Höjer; S Anséhn; A Thore
Journal:  Scand J Infect Dis       Date:  1977
  7 in total
  3 in total

1.  Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin.

Authors:  J N Walterspiel; S Feldman; R Van; W R Ravis
Journal:  Antimicrob Agents Chemother       Date:  1991-09       Impact factor: 5.191

Review 2.  Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  D M Campoli-Richards; S Chaplin; R H Sayce; K L Goa
Journal:  Drugs       Date:  1989-11       Impact factor: 9.546

3.  Analytical accuracy of determinations of aminoglycoside concentrations by enzyme multiplied immunoassay, fluorescence polarization immunoassay, and radioimmunoassay in the presence of heparin.

Authors:  M E O'Connell; K L Heim; C E Halstenson; G R Matzke
Journal:  J Clin Microbiol       Date:  1984-12       Impact factor: 5.948
  3 in total

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