Literature DB >> 7024024

Demonstration of glucagon in the stomach of human fetuses.

M Ravazzola, R H Unger, L Orci.   

Abstract

Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic alpha-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morphologic and immunocytochemical criteria from the pancreatic A-cells.

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Year:  1981        PMID： 7024024     DOI： 10.2337/diab.30.10.879

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  11 in total

1.  Immunohistochemical localization of glucagon-like peptide 1. Use of poly- and monoclonal antibodies.

Authors:  T Kauth; J Metz
Journal:  Histochemistry       Date:  1987

Review 2.  Gut endocrine and neural peptides.

Authors:  Anne E Bishop; Julia M Polak
Journal:  Endocr Pathol       Date:  1990-03       Impact factor: 3.943

3.  Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density.

Authors:  Olivera Mitrović; Mileva Mićić; Goran Radenković; Sanja Vignjević; Dragoslava Ðikić; Mirela Budeč; Tijana Breković; Vladan Čokić
Journal:  J Gastroenterol       Date:  2012-04-28       Impact factor: 7.527

4.  Histidyl-proline diketopiperazine (His-Pro DKP) immunoreactivity is present in the glucagon-containing cells of the human fetal pancreas.

Authors:  P Leduque; I M Jackson; A Kervran; S Aratan-Spire; P Czernichow; P M Dubois
Journal:  J Clin Invest       Date:  1987-03       Impact factor: 14.808

5.  Regulatory peptides in the gastrointestinal tract of Alligator mississipiensis. An immunocytochemical study.

Authors:  A M Buchan; V Lance; J M Polak
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

6.  Pancreatic glucagon in human foetal stomach.

Authors:  A M Buchan; M G Bryant; B A Stein; M Gregor; M A Ghatei; J F Morris; S R Bloom; J M Polak
Journal:  Histochemistry       Date:  1982

7.  Immunohistochemical studies on glucagon, glicentin and pancreatic polypeptide in human stomach: normal and pathological conditions.

Authors:  Y Tsutsumi
Journal:  Histochem J       Date:  1984-08

8.  Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.

Authors:  Young Lee; May-Yun Wang; Xiu Quan Du; Maureen J Charron; Roger H Unger
Journal:  Diabetes       Date:  2011-02       Impact factor: 9.461

9.  Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository.

Authors:  Fidéline Bonnet-Serrano; Marc Diedisheim; Roberto Mallone; Etienne Larger
Journal:  PLoS One       Date:  2018-01-19       Impact factor: 3.240

Review 10.  Insulin and Glucagon: Partners for Life.

Authors:  Jens Juul Holst; William Holland; Jesper Gromada; Young Lee; Roger H Unger; Hai Yan; Kyle W Sloop; Timothy J Kieffer; Nicolas Damond; Pedro L Herrera
Journal:  Endocrinology       Date:  2017-04-01       Impact factor: 4.736
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