| Literature DB >> 702308 |
Abstract
A crude extract of the leaves of Azadirachta indica was studied for its effects on the cardiovascular system of anesthetized guinea pigs and rabbits. These effects include profound hypotension and a minimal negative chronotropic effect, which increased at higher doses. In one rabbit, 200 mg of extract/kg decreased the heart rate from 280 to 150 beats/min. The extract also exhibited a weak antiarrhythmic activity in rabbits against ouabain-induced dysrhythmia.Entities:
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Year: 1978 PMID: 702308 DOI: 10.1002/jps.2600671044
Source DB: PubMed Journal: J Pharm Sci ISSN: 0022-3549 Impact factor: 3.534