Literature DB >> 702282

Pharmacokinetics of drug permeation through human skin.

S K Chandrasekaran, W Bayne, J E Shaw.   

Abstract

Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic system through human skin in vivo. Experimentally measured scopolamine delivery in vivo conformed to this model.

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Year:  1978        PMID： 702282     DOI： 10.1002/jps.2600671010

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  12 in total

Review 1.  Transdermal scopolamine for prevention of motion sickness : clinical pharmacokinetics and therapeutic applications.

Authors:  Zohar Nachum; Avi Shupak; Carlos R Gordon
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

2.  Kinetic analysis of transdermal nitroglycerin delivery.

Authors:  R H Guy; J Hadgraft
Journal:  Pharm Res       Date:  1985-09       Impact factor: 4.200

3.  The bioavailability of dermatological and other topically administered drugs.

Authors:  R H Guy; A H Guy; H I Maibach; V P Shah
Journal:  Pharm Res       Date:  1986-10       Impact factor: 4.200

4.  Novel pharmacokinetic modelling of transdermal nitroglycerin.

Authors:  B Auclair; G Sirois; A H Ngoc; M P Ducharme
Journal:  Pharm Res       Date:  1998-04       Impact factor: 4.200

5.  Transdermal delivery of narcotic analgesics: comparative permeabilities of narcotic analgesics through human cadaver skin.

Authors:  S D Roy; G L Flynn
Journal:  Pharm Res       Date:  1989-10       Impact factor: 4.200

6.  Pharmacokinetics and oral bioavailability of scopolamine in normal subjects.

Authors:  L Putcha; N M Cintrón; J Tsui; J M Vanderploeg; W G Kramer
Journal:  Pharm Res       Date:  1989-06       Impact factor: 4.200

Review 7.  Pharmacokinetic considerations in the use of newer transdermal formulations.

Authors:  G Ridout; G C Santus; R H Guy
Journal:  Clin Pharmacokinet       Date:  1988-08       Impact factor: 6.447

8.  In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum.

Authors:  F Yamashita; H Bando; Y Koyama; S Kitagawa; Y Takakura; M Hashida
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200

9.  Carboxylic ester hydrolase activity in hairless and athymic nude mouse skin.

Authors:  M K Ghosh; A K Mitra
Journal:  Pharm Res       Date:  1990-03       Impact factor: 4.200

10.  Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study.

Authors:  T Sunderland; G Esposito; S E Molchan; R Coppola; D W Jones; J Gorey; J T Little; M Bahro; D R Weinberger
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530
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