Literature DB >> 7022187

Analysis of mutagenic activity in cigarette smokers' urine by high performance liquid chromatography.

R M Putzrath, D Langley, E Eisenstadt.   

Abstract

Mutagenic activity in smokers' urine which had been concentrated by XAD-2 resin can be separated from approximately 90% of the non-mutagenic material by CH2Cl2 extraction. This extract appears to be stable for 3 months at -20 degrees C. High performance liquid chromatography analysis of the CH2Cl2 extract showed multiple mutagenic non-polar fractions which were better activated by rat liver homogenates prepared from 3-methylcholanthrene treated rats than from rats treated with phenobarbital. Mutagenic activity in smokers' urine was extractable by acid, but not by base. The mutagens in smokers' urine appear to be a complex mixture of relatively non-polar chemicals.

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Year:  1981        PMID： 7022187     DOI： 10.1016/0165-1161(81)90025-x

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  6 in total

1.  Mutagens in urine of carbon electrode workers.

Authors:  R Pasquini; S Monarca; G S Sforzolini; R Conti; F Fagioli
Journal:  Int Arch Occup Environ Health       Date:  1982       Impact factor: 3.015

2.  Cytogenetic effects of cigarette smoke condensates in vitro and in vivo.

Authors:  S Madle; A Korte; G Obe
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

3.  Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes.

Authors:  R Pasquini; S Monarca; G Scassellati Sforzolini; A Savino; F A Bauleo; G Angeli
Journal:  Int Arch Occup Environ Health       Date:  1989       Impact factor: 3.015

4.  Mutagenicity of urine from young male smokers and nonsmokers.

Authors:  H Kawano; T Inamasu; M Ishizawa; N Ishinishi; J Kumazawa
Journal:  Int Arch Occup Environ Health       Date:  1987       Impact factor: 3.015

5.  Mutagenicity studies in a tyre plant: in vitro activity of workers' urinary concentrates and raw materials.

Authors:  R Crebelli; A Paoletti; E Falcone; G Aquilina; G Fabri; A Carere
Journal:  Br J Ind Med       Date:  1985-07

6.  Biological monitoring of human exposure to coal tar. Urinary excretion of total polycyclic aromatic hydrocarbons, 1-hydroxypyrene and mutagens in psoriatic patients.

Authors:  E Clonfero; M Zordan; P Venier; M Paleologo; A G Levis; D Cottica; L Pozzoli; F J Jongeneelen; R P Bos; R B Anzion
Journal:  Int Arch Occup Environ Health       Date:  1989       Impact factor: 3.015
  6 in total

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