Literature DB >> 7021752

Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

M A Cremer, J A Pitcock, J M Stuart, A H Kang, A S Townes.   

Abstract

Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.

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Year:  1981        PMID： 7021752      PMCID： PMC2186432          DOI： 10.1084/jem.154.2.535

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  11 in total

1.  Relapsing polychondritis. Report of two cases with an immunopathological review.

Authors:  R W Gange
Journal:  Clin Exp Dermatol       Date:  1976-09       Impact factor: 3.470

2.  Relapsing polychondritis. Three cases with a clinico-pathological study and literature review.

Authors:  R A Hughes; C L Berry; M Seifert; M H Lessof
Journal:  Q J Med       Date:  1972-07

3.  Relapsing polychondritis: an autoimmune disease?

Authors:  R N Clayton; R Hoffenberg
Journal:  Br Med J       Date:  1978-10-07

4.  Relapsing polychondritis with positive direct immunofluorescence.

Authors:  W F Bergfeld
Journal:  Arch Dermatol       Date:  1978-01

5.  Relapsing polychondritis. Immunomicroscopic findings in cartilage of ear biopsy specimens.

Authors:  R Valenzuela; P A Cooperrider; P Gogate; S D Deodhar; W F Bergfeld
Journal:  Hum Pathol       Date:  1980-01       Impact factor: 3.466

6.  Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.

Authors:  C M PEARSON; B H WAKSMAN; J T SHARP
Journal:  J Exp Med       Date:  1961-03-01       Impact factor: 14.307

7.  Immunisation against heterologous type II collagen induces arthritis in mice.

Authors:  J S Courtenay; M J Dallman; A D Dayan; A Martin; B Mosedale
Journal:  Nature       Date:  1980-02-14       Impact factor: 49.962

8.  Antibodies to type II collagen in relapsing polychondritis.

Authors:  J M Foidart; S Abe; G R Martin; T M Zizic; E V Barnett; T J Lawley; S I Katz
Journal:  N Engl J Med       Date:  1978-11-30       Impact factor: 91.245

9.  Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.

Authors:  K Morgan; R B Clague; M J Shaw; P J Holt
Journal:  Ann Rheum Dis       Date:  1980-06       Impact factor: 19.103

10.  Collagen-induced arthritis in rats. Evaluation of early immunologic events.

Authors:  J M Stuart; M A Cremer; A H Kang; A S Townes
Journal:  Arthritis Rheum       Date:  1979-12
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  12 in total

Review 1.  The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases.

Authors:  Alina Sesarman; Gestur Vidarsson; Cassian Sitaru
Journal:  Cell Mol Life Sci       Date:  2010-03-09       Impact factor: 9.261

2.  Type II collagen induced bone resorption in the temporal bone of rats: histological and immunohistochemical studies.

Authors:  C C Huang; D Saporta; M Abramson
Journal:  Arch Otorhinolaryngol       Date:  1985

3.  A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1).

Authors:  A S Hansson; D Heinegård; R Holmdahl
Journal:  J Clin Invest       Date:  1999-09       Impact factor: 14.808

4.  Failure of calcitonin to inhibit collagen-induced arthritis in rats.

Authors:  J M Stuart; P R Bandy; R S Pinals; A S Townes
Journal:  Agents Actions       Date:  1982-12

5.  Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis.

Authors:  Veena Taneja; Marie Griffiths; Marshall Behrens; Harvinder S Luthra; Chella S David
Journal:  J Clin Invest       Date:  2003-12       Impact factor: 14.808

6.  Auricular chondritis in fawn-hooded rats. A spontaneous disorder resembling that induced by immunization with type II collagen.

Authors:  D J Prieur; D M Young; D F Counts
Journal:  Am J Pathol       Date:  1984-07       Impact factor: 4.307

7.  The absence of antibodies to type II collagen in established adjuvant arthritis in rats.

Authors:  F DeLustro; R P Carlson; L J Datko; B DeLustro; A J Lewis
Journal:  Agents Actions       Date:  1984-06

8.  Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease.

Authors:  Ann-Sofie Hansson; Martina Johannesson; Lars Svensson; Kutty Selda Nandakumar; Dick Heinegård; Rikard Holmdahl
Journal:  Am J Pathol       Date:  2004-03       Impact factor: 4.307

9.  Epididymo-orchitis as a presenting feature of relapsing polychondritis: a case report.

Authors:  Kuljeet Bhamra; Rachel Weerasinghe; Alan Steuer
Journal:  Case Rep Rheumatol       Date:  2012-01-04

10.  Collagen-induced arthritis in mice. Localization of an arthritogenic determinant to a fragment of the type II collagen molecule.

Authors:  K Terato; K A Hasty; M A Cremer; J M Stuart; A S Townes; A H Kang
Journal:  J Exp Med       Date:  1985-08-01       Impact factor: 14.307
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