Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Mixed pancreatic apudoma with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide.

Literature DB >> 7021331

Mixed pancreatic apudoma with symptoms of excess vasoactive intestinal polypeptide and insulin: improvement of diarrhoea with metoclopramide.

R G Long, M G Bryant, P M Yuille, J M Polak, S R Bloom.

Abstract

A female patient is described with a single pancreatic tumour producing vasoactive intestinal polypeptide (VIP), insulin, and pancreatic polypeptide. The initial presentation was with diarrhoea and hypokalaemia and a raised plasma VIP was demonstrated. Her symptoms improved with metoclopramide administration and absolute concentrations of 28 aminoacid (peak IV) VIP were found to have fallen. She then developed hypoglycaemia with hyperinsulinism. All symptoms resolved after surgical excision. This case emphasises the potential of these tumours to contain more than one endocrine cell type synthesising different biologically active peptides.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1981 PMID： 7021331 PMCID： PMC1419268 DOI： 10.1136/gut.22.6.505

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

29 in total

1. Bifunctional reagents as vapour- and liquid-phase fixatives for immunohistochemistry.

Authors: A G Pearse; J M Polak
Journal: Histochem J Date: 1975-03

2. Pancreatic islet cell carcinoma. I. Clinical features of 52 patients.

Authors: L E Broder; S K Carter
Journal: Ann Intern Med Date: 1973-07 Impact factor: 25.391

3. Multihormonal, amyloid-producing tumour of the islets of Langerhans in a twelve-year-old boy. Clinical, morphological and biochemical data and review of the literature.

Authors: P Heitz; H Steiner; F Halter; F Egli; J P Kapp
Journal: Virchows Arch A Pathol Pathol Anat Date: 1971

4. A glucagonoma syndrome.

Authors: C N Mallinson; S R Bloom; A P Warin; P R Salmon; B Cox
Journal: Lancet Date: 1974-07-06 Impact factor: 79.321

5. Vasoactive intestinal peptide and watery-diarrhoea syndrome.

Authors: S R Bloom; J M Polak; A G Pearse
Journal: Lancet Date: 1973-07-07 Impact factor: 79.321

6. In vitro studies of the rate of proinsulin and insulin turnover in seven human insulinomas.

Authors: C Creutzfeldt; N S Track; W Creutzfeldt
Journal: Eur J Clin Invest Date: 1973-09 Impact factor: 4.686

7. Secretion of various endocrine substances by ACTH-secreting tumors--gastrin, melanotropin, norepinephrine, serotonin, parathormone, vasopressin, glucagon.

Authors: L W O'Neal; D M Kipnis; S A Luse; P E Lacy; L Jarett
Journal: Cancer Date: 1968-06 Impact factor: 6.860

8. Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis.

Authors: F Santeusanio; G R Faloona; J P Knochel; R H Unger
Journal: J Lab Clin Med Date: 1973-06

9. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.

Authors: J D Albano; R P Ekins; G Maritz; R C Turner
Journal: Acta Endocrinol (Copenh) Date: 1972-07

10. Beneficial effect of oral lithium carbonate in the treatment of pancreatic cholera syndrome.

Authors: S J Pandol; L Y Korman; D M McCarthy; J D Gardner
Journal: N Engl J Med Date: 1980-06-19 Impact factor: 91.245

5 in total

1. Treatment of pancreatic cholera.

Authors: H Hagege; C Buffet; G Pelletier; A Roche; J P Etienne
Journal: Dig Dis Sci Date: 1988-01 Impact factor: 3.199

Review 2. Recent advances in pancreatic hormone research.

Authors: R G Long
Journal: Postgrad Med J Date: 1983-05 Impact factor: 2.401

3. Neuroendocrine tumors of the gut.

Authors: P Durning; R B Galland; D M Nagorney; R B Welbourn
Journal: World J Surg Date: 1985-04 Impact factor: 3.352

4. Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue symptomatic and peptide responses.

Authors: S M Wood; M E Kraenzlin; T E Adrian; S R Bloom
Journal: Gut Date: 1985-05 Impact factor: 23.059

5. Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Authors: William Y Chey; Wendy L Frankel; Sashwati Roy; Soma Datta; Chandan K Sen; Mary Dillhoff; Peter Muscarella; Konrad H Soergel; Ronald K Tompkins; Ta-Min Chang; Edward L Bradley; Edwin Christopher Ellison
Journal: Ann Surg Date: 2017-08 Impact factor: 12.969

5 in total