Literature DB >> 7021173

Effect of glucagon on ethanol oxidation in isolated rat liver cells.

M Mangeney-Andréani, F Beaugé, J Nordmann, R Nordmann.   

Abstract

Addition of glucagon 5 min after ethanol was found to stimulate the rate of ethanol oxidation in hepatocytes isolated from starved rats. This stimulation is of the same order of magnitude as that mediated by asparagine. The glucagon effect is suppressed by antiproteolytic agents such as insulin or NH4Cl. The stimulating effect of glucagon on ethanol oxidation is probably linked to enhanced proteolysis and an elevated glutamate level in the hepatocytes.

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Year:  1981        PMID： 7021173     DOI： 10.1007/bf01990039

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Reduced rates of proteolysis in transformed cells.

Authors:  J M Gunn; M G Clark; S E Knowles; M F Hopgood; F J Ballard
Journal:  Nature       Date:  1977-03-03       Impact factor: 49.962

2.  Effect of acute ethanol load on plasma immunoreactive insulin and glucagon.

Authors:  V P Jauhonen
Journal:  Horm Metab Res       Date:  1978-05       Impact factor: 2.936

3.  Inhibition of protein degradation in isolated rat hepatocytes.

Authors:  M F Hopgood; M G Clark; F J Ballard
Journal:  Biochem J       Date:  1977-05-15       Impact factor: 3.857

4.  Effects of glucagon on glutamate metabolism in the perfused rat liver.

Authors:  M Ui; J H Exton; C R Park
Journal:  J Biol Chem       Date:  1973-08-10       Impact factor: 5.157

5.  Effect of glucagon on the metabolism of ethanol in rat liver.

Authors:  A K Rawat
Journal:  Acta Chem Scand       Date:  1970

6.  The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.

Authors:  M A Titheradge; R C Haynes
Journal:  Arch Biochem Biophys       Date:  1980-04-15       Impact factor: 4.013

7.  Effect of glucocorticoids on amino acid transport in isolated rat hepatocytes.

Authors:  A Le Cam; P Freychet
Journal:  Mol Cell Endocrinol       Date:  1977-12       Impact factor: 4.102

8.  [Effect of natural amino acids on ethanol oxidation in isolated rat hepatocytes].

Authors:  M Mangeney; F Beaugé; J Nordmann; R Nordmann
Journal:  Arch Int Physiol Biochim       Date:  1979-08

9.  Ethanol oxidation by isolated rat-liver cells. Stimulatory effects of fructose.

Authors:  M N Berry; E Kun
Journal:  Eur J Biochem       Date:  1978-08-15

10.  Rate-limiting factors in the oxidation of ethanol by isolated rat liver cells.

Authors:  A J Meijer; G M van Woerkom; J R Williamson; J M Tager
Journal:  Biochem J       Date:  1975-08       Impact factor: 3.857
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