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Literature DB >> 702047

Leukocyte surface origin of human alpha1-acid glycoprotein (orosomucoid).

Abstract

Specific antibodies against human alpha1-acid glycoprotein reacted with human lymphocytes, granulocytes, and monocytes. The antigen on the leukocytes is an externally located integral membrane glycoprotein which is made by the cells and has an apparent mol wt of 52,000. It is released from cells in vitro to the culture medium. The mol wt of the soluble fragment is 41,000, which corresponds to that of alpha1-acid glycoprotein in serum and urine. Peptide mapping confirmed that the main part of the cellular membrane antigen consists of alpha1-acid glycoprotein with an additional, probably hydrophobic fragment. This finding may partially explain the increase in the serum levels of alpha1-acid glycoprotein observed in many disorders involving leukocyte proliferation. In addition, the known sequence homology of alpha1-acid glycoprotein with immunoglobulins can now be more easily understood by their origin in similar cell types.

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Year: 1978 PMID： 702047 PMCID： PMC2184935 DOI： 10.1084/jem.148.2.507

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

29 in total

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Journal: J Biol Chem Date: 1959-08 Impact factor: 5.157

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Authors: E J SARCIONE
Journal: Arch Biochem Biophys Date: 1963-03 Impact factor: 4.013

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Authors: K M Chiu; R F Mortensen; A P Osmand; H Gewurz
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Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

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Journal: J Biol Chem Date: 1950-08 Impact factor: 5.157

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Journal: Int J Cancer Date: 1977-11-15 Impact factor: 7.396

8. Cortisone as a probe for cell interactions in the generation of cytotoxic T cells. I. Effect on helper cells, cytotoxic T cell precursors, and accessory cells.

Authors: K C Lee
Journal: J Immunol Date: 1977-11 Impact factor: 5.422

9. Detergent solubilization, purification, and separation of specificities of HLA antigens from a cultured human lymphoblastoid line, RPMI 4265.

Authors: T A Springer; D L Mann; A L DeFranco; J L Strominger
Journal: J Biol Chem Date: 1977-07-10 Impact factor: 5.157

10. Characterization of surface glycoproteins of mouse lymphoid cells.

Authors: C G Gahmberg; P Häyry; L C Andersson
Journal: J Cell Biol Date: 1976-03 Impact factor: 10.539

34 in total

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Journal: Folia Microbiol (Praha) Date: 2003 Impact factor: 2.099

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Authors: B E Turk; H Jiang; J O Liu
Journal: Proc Natl Acad Sci U S A Date: 1996-07-23 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1984-11 Impact factor: 11.205

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Authors: L C Andersson; C G Gahmberg
Journal: Mol Cell Biochem Date: 1979-10-15 Impact factor: 3.396

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Authors: T Krusius; J Finne; L C Andersson; C G Gahmberg
Journal: Biochem J Date: 1979-08-01 Impact factor: 3.857

6. Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Authors: T Hochepied; A Wullaert; F G Berger; H Baumann; P Brouckaert; L Steidler; C Libert
Journal: Gut Date: 2002-09 Impact factor: 23.059

7. Modulation of alpha 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development.

Authors: M Yiangou; C Konidaris; P Victoratos; L Hadjipetrou-Kourounakis
Journal: Clin Exp Immunol Date: 1993-10 Impact factor: 4.330

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Authors: C G Gahmberg; K Nilsson; L C Andersson
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

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Authors: D A Cheresh; D H Haynes; J A Distasio
Journal: Immunology Date: 1984-03 Impact factor: 7.397

10. The increased excretion of urinary orosomucoid 1 as a useful biomarker for bladder cancer.

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Journal: Am J Cancer Res Date: 2016-01-15 Impact factor: 6.166