Literature DB >> 7019245

Impairment of the growth of Plasmodium falciparum in HbEE erythrocytes.

R L Nagel, C Raventos-Suarez, M E Fabry, H Tanowitz, D Sicard, D Labie.   

Abstract

HbE is a beta-chain mutant frequently found among inhabitants of Southeast Asia and surrounding territories. We find that Plasmodium falciparum multiplies more slowly in erythrocytes from individuals homozygous for HbE than in cells from HbA individuals. In contrast, this parasite grows normally in erythrocytes heterozygous for HbE. This is the first direct evidence that suggests what has been suspected on the basis of circumstantial data, that HbE-containing erythrocytes might be advantageous to the carrier in regions with endemic malaria.

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Year:  1981        PMID： 7019245      PMCID： PMC370798          DOI： 10.1172/jci110248

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  10 in total

1.  Abnormal human haemoglobins. VI. The chemical difference between haemoglobins A and E.

Authors:  J A HUNT; V M INGRAM
Journal:  Biochim Biophys Acta       Date:  1961-05-27

2.  Oxidant damage mediates variant red cell resistance to malaria.

Authors:  M J Friedman
Journal:  Nature       Date:  1979-07-19       Impact factor: 49.962

3.  A new density gradient system for the separation of human red blood cells.

Authors:  L Vettore; M C De Matteis; P Zampini
Journal:  Am J Hematol       Date:  1980       Impact factor: 10.047

4.  High genetic polymorphism of hemoglobin disorders in Laos. Complex phenotypes due to associated thalassemic syndromes.

Authors:  D Sicard; Y Lieurzou; C Lapoumeroulie; D Labie
Journal:  Hum Genet       Date:  1979-09       Impact factor: 4.132

5.  Hemoglobin E: distribution and population dynamics.

Authors:  G Flatz
Journal:  Humangenetik       Date:  1967

6.  Hemoglobin E, an oxidatively unstable mutation.

Authors:  H Frischer; J Bowman
Journal:  J Lab Clin Med       Date:  1975-04

7.  Defective synthesis of HbE is due to reduced levels of beta E mRNA.

Authors:  J Traeger; W G Wood; J B Clegg; D J Weatherall
Journal:  Nature       Date:  1980-12-04       Impact factor: 49.962

8.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

9.  Homozygous hemoglobin E mimics beta-thalassemia minor without anemia or hemolysis: hematologic, functional, and biosynthetic studies of first North American cases.

Authors:  V F Fairbanks; R Oliveros; J H Brandabur; R R Willis; R F Fiester
Journal:  Am J Hematol       Date:  1980       Impact factor: 10.047

10.  Effect of sodium cyanate on Plasmodium falciparum in vitro.

Authors:  R L Nagel; C Raventos; H B Tanowitz; M Wittner
Journal:  J Parasitol       Date:  1980-06       Impact factor: 1.276
  10 in total
  13 in total

1.  Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area.

Authors:  Yan He; Susana Campino; Ernest Diez Benavente; David C Warhurst; Khalid B Beshir; Inke Lubis; Ana Rita Gomes; Jun Feng; Wang Jiazhi; Xiaodong Sun; Fang Huang; Lin-Hua Tang; Colin J Sutherland; Taane G Clark
Journal:  PLoS One       Date:  2019-03-18       Impact factor: 3.240

2.  Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children.

Authors:  Patrick T McGann; Anne M Williams; Graham Ellis; Kathryn E McElhinney; Laurel Romano; Julia Woodall; Thad A Howard; Gerald Tegha; Robert Krysiak; R Murray Lark; E Louise Ander; Carine Mapango; Kenneth I Ataga; Satish Gopal; Nigel S Key; Russell E Ware; Parminder S Suchdev
Journal:  Blood Adv       Date:  2018-11-13

3.  Genetic red cell disorders and severity of falciparum malaria in Myanmar.

Authors:  M Oo; W J O'Sullivan
Journal:  Bull World Health Organ       Date:  1995       Impact factor: 9.408

4.  Salmonella Typhi and Plasmodium falciparum co-infection in a 12-year old girl with haemoglobin E trait from a non-malarious area in Bangladesh.

Authors:  Fahmida Chowdhury; Mohammod J Chisti; Ahmadul H Khan; Mohammad A Chowdhury; Mark A C Pietroni
Journal:  J Health Popul Nutr       Date:  2010-10       Impact factor: 2.000

5.  Artemisinin Therapy for Malaria in Hemoglobinopathies: A Systematic Review.

Authors:  Sri Riyati Sugiarto; Brioni R Moore; Julie Makani; Timothy M E Davis
Journal:  Clin Infect Dis       Date:  2018-02-10       Impact factor: 9.079

6.  Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.

Authors:  I A Clark; N H Hunt
Journal:  Infect Immun       Date:  1983-01       Impact factor: 3.441

7.  Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border.

Authors:  Zeshuai Deng; Qing Li; Haoan Yi; Yanjie Zhang; Fang Yang; Hong Li; Lan Luo; Limei Ma; Zhaoqing Yang; Yongshu He; Liwang Cui
Journal:  J Infect       Date:  2018-06-28       Impact factor: 6.072

8.  The host genetic diversity in malaria infection.

Authors:  Vitor R R de Mendonça; Marilda Souza Goncalves; Manoel Barral-Netto
Journal:  J Trop Med       Date:  2012-12-13

Review 9.  Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis.

Authors:  Steve M Taylor; Carla Cerami; Rick M Fairhurst
Journal:  PLoS Pathog       Date:  2013-05-16       Impact factor: 6.823

Review 10.  The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?

Authors:  Patrick M Lelliott; Brendan J McMorran; Simon J Foote; Gaetan Burgio
Journal:  Malar J       Date:  2015-07-29       Impact factor: 2.979
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