Literature DB >> 7018169

Diazepam rectal solution for home treatment of acute seizures in children.

K Hoppu, P Santavuori.   

Abstract

To gain clinical experience of treating acute convulsions in children with diazepam rectal solution, 17 epileptic children with prolonged convulsions were treated at home. The drug was used 65 times. On 2/3 of all occasions the seizure was interrupted in less than 15 min. A starting dose of 0.5 mg/kg is recommended, with a maximum of 20 mg per single dose. One patient had respiratory difficulties, one dizziness and two skin reactions.

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Year:  1981        PMID: 7018169     DOI: 10.1111/j.1651-2227.1981.tb16565.x

Source DB:  PubMed          Journal:  Acta Paediatr Scand        ISSN: 0001-656X


  8 in total

Review 1.  Emergency treatment of acute seizures and status epilepticus.

Authors:  R C Tasker
Journal:  Arch Dis Child       Date:  1998-07       Impact factor: 3.791

2.  Long term prophylaxis of febrile seizures.

Authors:  K Ramakrishnan; K Thomas
Journal:  Indian J Pediatr       Date:  1986 May-Jun       Impact factor: 1.967

Review 3.  The treatment of convulsive status epilepticus in children. The Status Epilepticus Working Party, Members of the Status Epilepticus Working Party.

Authors:  R Appleton; I Choonara; T Martland; B Phillips; R Scott; W Whitehouse
Journal:  Arch Dis Child       Date:  2000-11       Impact factor: 3.791

4.  Long term outcome of prophylaxis for febrile convulsions.

Authors:  F U Knudsen; A Paerregaard; R Andersen; J Andresen
Journal:  Arch Dis Child       Date:  1996-01       Impact factor: 3.791

5.  Absorption and safety of rectally administered phenytoin.

Authors:  R H Fuerst; N M Graves; R L Kriel; R Olson
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Oct-Dec       Impact factor: 2.441

Review 6.  Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment.

Authors:  John M Pellock
Journal:  Drug Saf       Date:  2004       Impact factor: 5.606

7.  CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study.

Authors:  Stephanie Ohlraun; Tobias Wollersheim; Claudia Weiß; Peter Martus; Steffen Weber-Carstens; Dietmar Schmitz; Markus Schuelke
Journal:  J Transl Med       Date:  2013-06-27       Impact factor: 5.531

Review 8.  Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.

Authors:  Adam Strzelczyk; Laurent M Willems; Ricardo Kienitz; Lara Kay; Isabelle Beuchat; Sarah Gelhard; Sophie von Brauchitsch; Catrin Mann; Alexandra Lucaciu; Jan-Hendrik Schäfer; Kai Siebenbrodt; Johann-Philipp Zöllner; Susanne Schubert-Bast; Felix Rosenow
Journal:  CNS Drugs       Date:  2022-08-16       Impact factor: 6.497

  8 in total

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