Literature DB >> 7016712

A sensitive method for the demonstration of senile plaques in the dementing brain.

J H Dowson.   

Abstract

Senile plaques occur mainly in the cerebral grey matter and are increased in senile dementia of the Alzheimer type. A new method for the demonstration of senile plaques is described which consists of irradiating unstained paraffin wax embedded sections with ultraviolet light. Senile plaques exhibit blue autofluorescence which is usually clearly visible against the background autofluorescence of the neuropil.

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Year:  1981        PMID： 7016712     DOI： 10.1111/j.1365-2559.1981.tb01789.x

Source DB:  PubMed          Journal:  Histopathology        ISSN： 0309-0167            Impact factor:   5.087


  7 in total

1.  Imaging and Spectral Characteristics of Amyloid Plaque Autofluorescence in Brain Slices from the APP/PS1 Mouse Model of Alzheimer's Disease.

Authors:  Yunling Gao; Qing Liu; Lingling Xu; Ning Zheng; Xiaoming He; Fuqiang Xu
Journal:  Neurosci Bull       Date:  2019-05-24       Impact factor: 5.203

2.  Additive-color multi-harmonic generation microscopy for simultaneous label-free differentiation of plaques, tangles, and neuronal axons.

Authors:  Sandeep Chakraborty; Sheng-Tse Chen; Yang-Ting Hsiao; Ming-Jang Chiu; Chi-Kuang Sun
Journal:  Biomed Opt Express       Date:  2020-01-02       Impact factor: 3.732

3.  Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease.

Authors:  Jennifer D Whitesell; Alex R Buckley; Joseph E Knox; Leonard Kuan; Nile Graddis; Andrew Pelos; Alice Mukora; Wayne Wakeman; Phillip Bohn; Anh Ho; Karla E Hirokawa; Julie A Harris
Journal:  J Comp Neurol       Date:  2018-12-04       Impact factor: 3.215

4.  Clusterin Binding Modulates the Aggregation and Neurotoxicity of Amyloid-β(1-42).

Authors:  Yun-Mi Kim; SuJi Park; Su Yeon Choi; Shin Bi Oh; MinKyo Jung; Chan-Gi Pack; Jung Jin Hwang; Eunyoung Tak; Joo-Yong Lee
Journal:  Mol Neurobiol       Date:  2022-07-29       Impact factor: 5.682

5.  Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.

Authors:  Alex C Kwan; Karen Duff; Gunnar K Gouras; Watt W Webb
Journal:  Opt Express       Date:  2009-03-02       Impact factor: 3.894

6.  The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model.

Authors:  Sivaraman Purushothuman; Lauren Marotte; Sally Stowe; Daniel M Johnstone; Jonathan Stone
Journal:  PLoS One       Date:  2013-03-21       Impact factor: 3.240

7.  Thiophene-Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer's Disease.

Authors:  Therése Klingstedt; Hamid Shirani; Bernardino Ghetti; Ruben Vidal; K Peter R Nilsson
Journal:  Chembiochem       Date:  2021-06-21       Impact factor: 3.164
  7 in total

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