Literature DB >> 7016112

A neutral endopeptidase in the microvillar membrane of pig intestine. Partial purification and properties.

E M Danielsen, J P Vyas, A J Kenny.   

Abstract

An enzyme hydrolysing [125I]iodo-insulin B chain was enriched in preparations of intestinal microvilli. The activity could be solubilized by Triton X-100 and was partially (76-fold) purified. It was very sensitive to inhibition by phosphoramidon and was also inhibited by chelating agents. In its enzymic, molecular and immunological properties the intestinal enzyme closely resembled kidney microvillar neutral endopeptidase (kidney-brush-border neutral proteinase, EC 3.4.24.11).

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Year:  1980        PMID： 7016112      PMCID： PMC1162257          DOI： 10.1042/bj1910645

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

Review 1.  Solubilization of membranes by detergents.

Authors:  A Helenius; K Simons
Journal:  Biochim Biophys Acta       Date:  1975-03-25

2.  A rat kidney neutral peptidase that degrades B chain of insulin, glucagon, and ACTH: purification by affinity chromatography and some properties.

Authors:  P T Varandani; L A Shroyer
Journal:  Arch Biochem Biophys       Date:  1977-05       Impact factor: 4.013

Review 3.  Microvilli: their ultrastructure, enzymology and molecular organization.

Authors:  A J Kenny; A G Booth
Journal:  Essays Biochem       Date:  1978       Impact factor: 8.000

4.  Purification of different amphiphilic forms of a microvillus aminopeptidase from pig small intestine using immunoadsorbent chromatography.

Authors:  H Sjöström; O Norén; L Jeppesen; M Staun; B Svensson; L Christiansen
Journal:  Eur J Biochem       Date:  1978-08-01

5.  A rapid method for the preparation of microvilli from rabbit kidney.

Authors:  A G Booth; A J Kenny
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

6.  Letter: A thermolysin inhibitor produced by Actinomycetes: phospholamidon.

Authors:  H Suda; T Aoyagi; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1973-10       Impact factor: 2.649

7.  Structural and topological homology between porcine intestinal and renal brush border aminopeptidase.

Authors:  C Vannier; D Louvard; S Maroux; P Desnuelle
Journal:  Biochim Biophys Acta       Date:  1976-11-11

8.  Studies on the enzymology of purified preparations of brush border from rabbit kidney.

Authors:  S G George; J Kenny
Journal:  Biochem J       Date:  1973-05       Impact factor: 3.857

9.  The purification and specificity of a neutral endopeptidase from rabbit kidney brush border.

Authors:  M A Kerr; A J Kenny
Journal:  Biochem J       Date:  1974-03       Impact factor: 3.857

10.  The molecular weight and properties of a neutral metallo-endopeptidase from rabbit kidney brush border.

Authors:  M A Kerr; A J Kenny
Journal:  Biochem J       Date:  1974-03       Impact factor: 3.857
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  16 in total

1.  Relationship between biological behavior and phenotypic expression in undifferentiated-type gastric carcinomas.

Authors:  Akira Kabashima; Takashi Yao; Yoshihiko Maehara; Masazumi Tsuneyoshi
Journal:  Gastric Cancer       Date:  2005       Impact factor: 7.370

2.  Extremely well-differentiated adenocarcinoma of the stomach: clinicopathological and immunohistochemical features.

Authors:  Takashi Yao; Takashi Utsunomiya; Masafumi Oya; Kenichi Nishiyama; Masazumi Tsuneyoshi
Journal:  World J Gastroenterol       Date:  2006-04-28       Impact factor: 5.742

3.  An immunoradiometric assay for endopeptidase-24.11 shows it to be a widely distributed enzyme in pig tissues.

Authors:  N S Gee; M A Bowes; P Buck; A J Kenny
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857

4.  Interaction of mammalian neprilysin with binding protein and calnexin in Schizosaccharomyces pombe.

Authors:  H Beaulieu; A Elagöz; P Crine; L A Rokeach
Journal:  Biochem J       Date:  1999-06-15       Impact factor: 3.857

5.  Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.

Authors:  R Matsas; I S Fulcher; A J Kenny; A J Turner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

6.  A monoclonal antibody to kidney endopeptidase-24.11. Its application in immunoadsorbent purification of the enzyme and immunofluorescent microscopy of kidney and intestine.

Authors:  N S Gee; R Matsas; A J Kenny
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

7.  Endopeptidase-24.11 purified from pig intestine is differently glycosylated from that in kidney.

Authors:  I S Fulcher; M F Chaplin; A J Kenny
Journal:  Biochem J       Date:  1983-11-01       Impact factor: 3.857

8.  Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias.

Authors:  Naoyuki Homma; Gen Tamura; Teiichiro Honda; Zhe Jin; Kiyonari Ohmura; Sumio Kawata; Teiichi Motoyama
Journal:  Virchows Arch       Date:  2004-12-10       Impact factor: 4.064

9.  Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide.

Authors:  J C Connelly; R A Skidgel; W W Schulz; A R Johnson; E G Erdös
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

Review 10.  Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery.

Authors:  J P Bai; G L Amidon
Journal:  Pharm Res       Date:  1992-08       Impact factor: 4.200
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