Literature DB >> 7015504

Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes.

M Baudry, M C Bundman, E K Smith, G S Lynch.   

Abstract

Incubation of cortical synaptic membranes with low concentrations of calcium resulted in a decrease in the amount of a high-molecular-weight doublet protein and an increase in the sodium-independent binding of glutamate. Both effects were blocked by the thiol protease inhibitor leupeptin. These results suggest that calcium-induced proteolysis of membrane components regulates the number of glutamate receptors in neuronal membranes.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7015504     DOI： 10.1126/science.7015504

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

Review 1.  Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA.

Authors:  L N Robin; M Kalloniatis
Journal:  Doc Ophthalmol       Date:  1992       Impact factor: 2.379

Review 2.  Regulation of calpain-2 in neurons: implications for synaptic plasticity.

Authors:  Sohila Zadran; Xiaoning Bi; Michel Baudry
Journal:  Mol Neurobiol       Date:  2010-10-06       Impact factor: 5.590

Review 3.  Calpain and synaptic function.

Authors:  Hai-Yan Wu; David R Lynch
Journal:  Mol Neurobiol       Date:  2006-06       Impact factor: 5.590

4.  Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia.

Authors:  T F Freund; G Buzsáki; A Leon; K G Baimbridge; P Somogyi
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

5.  Calcium-activated neutral protease activities in brain trauma.

Authors:  E Arrigoni; F Cohadon
Journal:  Neurochem Res       Date:  1991-04       Impact factor: 3.996

6.  The regional and subcellular distribution of calcium activated neutral proteinase (CANP) in the bovine central nervous system.

Authors:  A K Chakrabarti; N L Banik; J M Powers; E L Hogan
Journal:  Neurochem Res       Date:  1989-03       Impact factor: 3.996

7.  Post-translational modification of neuronal proteins: evidence for transglutaminase activity in R2, the giant cholinergic neuron of Aplysia.

Authors:  R T Ambron; L T Kremzner
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

8.  Characterization of the binding of DL-[3H]-2-amino-4-phosphonobutyrate to L-glutamate-sensitive sites on rat brain synaptic membranes.

Authors:  S P Butcher; J F Collins; P J Roberts
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

9.  Binding sites for L-glutamate in the central nervous system of the rat.

Authors:  A P Larder; H McLennan
Journal:  Neurochem Res       Date:  1984-03       Impact factor: 3.996

Review 10.  The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states.

Authors:  P W Vanderklish; B A Bahr
Journal:  Int J Exp Pathol       Date:  2000-10       Impact factor: 1.925
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.