Literature DB >> 7013577

Evidence of cytocidal effects of Pasteurella haemolytica on bovine peripheral blood mononuclear leukocytes.

K L Kaehler, R J Markam, C C Muscoplat, D W Johnson.   

Abstract

Pasteurella haemolytica had a pronounced cytocidal effect on bovine mononuclear leukocytes. Mononuclear leukocytes separated from venous blood on Ficoll-diatrizoate and incubated with either P haemolytica or Escherichia coli showed a significantly greater percentage cell death than did cells incubated with Staphylococcus epidermidis or controls. Neither heat-killed nor x-irradiated P haemolytica caused a significant percentage cell death. The cytotoxic potential of P haemolytica was dose related in that cell death among mononuclear leukocytes increased as the ratio of bacteria-to-cells increased. Enriched monocyte cultures showed a higher and less variable rate of cell death than either enriched lymphocyte or mixed leukocyte cultures.

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Year:  1980        PMID： 7013577

Source DB:  PubMed          Journal:  Am J Vet Res        ISSN： 0002-9645            Impact factor:   1.156


  26 in total

1.  In vitro lymphocyte proliferative responses and gamma-interferon production as measures of cell-mediated immunity of cattle exposed to Pasteurella haemolytica.

Authors:  B M DeBey; J A Roth; K A Brogden; R C Cutlip; M G Stevens; T Jones; R E Briggs; J P Kluge
Journal:  Can J Vet Res       Date:  1996-10       Impact factor: 1.310

2.  Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant.

Authors:  C A Strathdee; R Y Lo
Journal:  J Bacteriol       Date:  1989-02       Impact factor: 3.490

3.  Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model.

Authors:  S K Highlander; N D Fedorova; D M Dusek; R Panciera; L E Alvarez; C Rinehart
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

4.  Effect of repeated in vitro transfer of Pasteurella haemolytica A1 on encapsulation, leukotoxin production, and virulence.

Authors:  M J Gentry; A W Confer; R C Craven
Journal:  J Clin Microbiol       Date:  1987-01       Impact factor: 5.948

5.  Anticytotoxin activity of bovine sera and body fluids against Pasteurella haemolytica A1 cytotoxin.

Authors:  H J Cho; J G Bohac; W D Yates; H Bielefeldt Ohmann
Journal:  Can J Comp Med       Date:  1984-04

6.  Molecular studies of Ssa1, a serotype-specific antigen of Pasteurella haemolytica A1.

Authors:  R Y Lo; C A Strathdee; P E Shewen; B J Cooney
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

7.  Exposure of calves to aerosols of parainfluenza-3 virus and Pasteurella haemolytica.

Authors:  P D Carrière; M G Maxie; B N Wilkie; M Savan; V E Valli; J A Johnson
Journal:  Can J Comp Med       Date:  1983-10

8.  Three contiguous lipoprotein genes in Pasteurella haemolytica A1 which are homologous to a lipoprotein gene in Haemophilus influenzae type b.

Authors:  B J Cooney; R Y Lo
Journal:  Infect Immun       Date:  1993-11       Impact factor: 3.441

Review 9.  A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle.

Authors:  W D Yates
Journal:  Can J Comp Med       Date:  1982-07

10.  Sequence diversity and molecular evolution of the heat-modifiable outer membrane protein gene (ompA) of Mannheimia(Pasteurella) haemolytica, Mannheimia glucosida, and Pasteurella trehalosi.

Authors:  Robert L Davies; Inkyoung Lee
Journal:  J Bacteriol       Date:  2004-09       Impact factor: 3.490
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