Literature DB >> 7013344

[Some experience with the enzymatic digestion of liver tissue by means of subtilisin Carlsberg (author's transl)].

E Klug.   

Abstract

According to the literature, the use of Subtilisin Carlsberg for the enzymatic digestion of tissue is supposed to yield significantly higher findings of barbiturates, alkaline substances, and benzodiazepins than traditional methods. In the case of 11 liver specimens, however, a comparison with a modified acetone method (extraction by ultrasonics) did not lead to an improvement in the results, nor did it facilitate preparation of the specimens.

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Year:  1981        PMID： 7013344     DOI： 10.1007/bf00201276

Source DB:  PubMed          Journal:  Z Rechtsmed        ISSN： 0044-3433


  6 in total

1.  [Detection of the renal excretion products of sedatives].

Authors:  E VIDIC; K GOEBEL
Journal:  Arch Toxikol       Date:  1961

2.  [The forensic value of methods of toxicological investigations].

Authors:  G Schmidt
Journal:  Beitr Gerichtl Med       Date:  1969

3.  The release of basic drugs by the enzymic digestion of tissues in cases of poisoning.

Authors:  M D Osselton
Journal:  J Forensic Sci Soc       Date:  1978 Apr-Jul

4.  The release of alkaloids from body tissues by protein precipitating reagents.

Authors:  H M Stevens; P Owen; V W Bunker
Journal:  J Forensic Sci Soc       Date:  1978 Apr-Jul

5.  Enzymic digestion of liver tissue to release barbiturates, salicylic acid and other acidic compounds in cases of human poisoning.

Authors:  M D Osselton; I C Shaw; H M Stevens
Journal:  Analyst       Date:  1978-11       Impact factor: 4.616

6.  The extraction and analysis of benzodiazepines in tissues by enzymic digestion and high-performance liquid chromatography.

Authors:  M D Osselton; M D Hammond; P J Twitchett
Journal:  J Pharm Pharmacol       Date:  1977-08       Impact factor: 3.765
  6 in total

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