| Literature DB >> 7013068 |
R Weinstein, M B Stemerman, T Maciag.
Abstract
In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.Entities:
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Year: 1981 PMID： 7013068 DOI： 10.1126/science.7013068
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728