Literature DB >> 7011974

Evidence that botulinum C2 toxin has two dissimilar components.

M Iwasaki, I Ohishi, G Sakaguchi.   

Abstract

Botulinum C2 toxin produced by most toxigenic and nontoxigenic strains of Clostridium botulinum types C and D contains two distinct protein components, and these were separated by ion-exchange chromatography and gel filtration. Neither of these components manifested the original toxicity, but the original toxicity was restored when the two components were mixed together and trypsinized. This indicates that C2 toxin consists of two dissimilar protein components and that the cooperation of the two is required to elicit toxicity.

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Year:  1980        PMID： 7011974      PMCID： PMC551130          DOI： 10.1128/iai.29.2.390-394.1980

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Activation of Clostridium botulinum type E toxin by trypsin.

Authors:  J T DUFF; G G WRIGHT; A YARINSKY
Journal:  J Bacteriol       Date:  1956-10       Impact factor: 3.490

2.  Clostridium botulinum type D toxin: purification, molecular structure, and some immunological properties.

Authors:  S Miyazaki; M Iwasaki; G Sakaguchi
Journal:  Infect Immun       Date:  1977-08       Impact factor: 3.441

3.  Sporulation and C2 toxin production by Clostridium botulinum type C strains producing no C1 toxin.

Authors:  S Nakamura; T Serikawa; K Yamakawa; S Nishida; S Kozaki; G Sakaguchi
Journal:  Microbiol Immunol       Date:  1978       Impact factor: 1.955

4.  Acid precipitation of Clostridium botulinum type C and D toxins from whole culture by addition of ribonucleic acid as a precipitation aid.

Authors:  M Iwasaki; G Sakaguchi
Journal:  Infect Immun       Date:  1978-02       Impact factor: 3.441

5.  Activation of a toxic component of Clostridium botulinum types C and D by trypsin.

Authors:  M W Eklund; F T Poysky
Journal:  Appl Microbiol       Date:  1972-07

6.  Separation of toxin and hemagglutinin from crystalline toxin of Clostridium botulinum type A by anion exchange chromatography and determination of their dimensions by gel filtration.

Authors:  B R DasGupta; D A Boroff
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

7.  The toxic antigenic factors produced by Clostridium botulinum types C and D.

Authors:  B C Jansen
Journal:  Onderstepoort J Vet Res       Date:  1971-06       Impact factor: 1.792

8.  Activation of botulinum toxins in the absence of nicking.

Authors:  I Ohishi; G Sakaguchi
Journal:  Infect Immun       Date:  1977-08       Impact factor: 3.441

9.  Enrichment, isolation, and cultural characteristics of marine strains of Clostridium botulinum type C.

Authors:  W P Segner; C F Schmidt; J K Boltz
Journal:  Appl Microbiol       Date:  1971-12

10.  Molecular construction of Clostridium botulinum type A toxins.

Authors:  S Sugii; G Sakaguchi
Journal:  Infect Immun       Date:  1975-12       Impact factor: 3.441
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  25 in total

1.  Clostridium perfringens iota-toxin: mapping of receptor binding and Ia docking domains on Ib.

Authors:  J C Marvaud; T Smith; M L Hale; M R Popoff; L A Smith; B G Stiles
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

2.  Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases.

Authors:  L L Simpson; B G Stiles; H Zepeda; T D Wilkins
Journal:  Infect Immun       Date:  1989-01       Impact factor: 3.441

Review 3.  Toxigenic clostridia.

Authors:  C L Hatheway
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

4.  Molecular gene profiling of Clostridium botulinum group III and its detection in naturally contaminated samples originating from various European countries.

Authors:  Cedric Woudstra; Caroline Le Maréchal; Rozenn Souillard; Marie-Hélène Bayon-Auboyer; Fabrizio Anniballi; Bruna Auricchio; Dario De Medici; Luca Bano; Miriam Koene; Marie-Hélène Sansonetti; Denise Desoutter; Eva-Maria Hansbauer; Martin B Dorner; Brigitte G Dorner; Patrick Fach
Journal:  Appl Environ Microbiol       Date:  2015-01-30       Impact factor: 4.792

5.  Purification and characterization of neurotoxin produced by Clostridium botulinum type C 6813.

Authors:  J Terajima; B Syuto; J O Ochanda; S Kubo
Journal:  Infect Immun       Date:  1985-05       Impact factor: 3.441

6.  Neurotoxin gene profiling of clostridium botulinum types C and D native to different countries within Europe.

Authors:  Cedric Woudstra; Hanna Skarin; Fabrizio Anniballi; Lucia Fenicia; Luca Bano; Ilenia Drigo; Miriam Koene; Marie-Hélène Bäyon-Auboyer; Jean-Philippe Buffereau; Dario De Medici; Patrick Fach
Journal:  Appl Environ Microbiol       Date:  2012-02-17       Impact factor: 4.792

7.  Partial characterization of the enzymatic activity associated with the binary toxin (type C2) produced by Clostridium botulinum.

Authors:  L L Simpson; H Zepeda; I Ohishi
Journal:  Infect Immun       Date:  1988-01       Impact factor: 3.441

8.  Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex.

Authors:  Bradley G Stiles; Martha L Hale; Jean Christophe Marvaud; Michel R Popoff
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857

Review 9.  Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.

Authors:  Holger Barth; Klaus Aktories; Michel R Popoff; Bradley G Stiles
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

10.  Characterization of an inducible bacteriophage from a leukotoxic strain of Actinobacillus actinomycetemcomitans.

Authors:  R H Stevens; B F Hammond; C H Lai
Journal:  Infect Immun       Date:  1982-01       Impact factor: 3.441
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