Effects of cyproheptadine on insulin-induced hypoglycaemia secretion of PRL, GH and cortisol.

The effect of cyproheptadine hydrochloride on release of prolactin (PRL), growth hormone (GH) and cortisol following insulin-induced hypoglycaemia was investigated in a group of eight adult female and male subjects. The results of this study demonstrated that cyproheptadine does not influence the release of these three hormones under the conditions employed in this study. The conflicting observation concerning the action of cyproheptadine on pituitary function as reported in the literature, may be a reflection of the diversity of pharmacological actions of this drug. Thus, any purported influence this drug might have on pituitary hormonal release should be interpreted with caution.