Literature DB >> 7010607

Cadmium-113 nuclear magnetic resonance studies of bovine insulin: two-zinc insulin hexamer specifically binds calcium.

J L Sudmeier, S J Bell, M C Storm, M F Dunn.   

Abstract

By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion binding sites.

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Year:  1981        PMID： 7010607     DOI： 10.1126/science.7010607

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Use of (113)Cd NMR to probe the native metal binding sites in metalloproteins: an overview.

Authors:  Ian M Armitage; Torbjörn Drakenberg; Brian Reilly
Journal:  Met Ions Life Sci       Date:  2013

2.  Testing of insulin hexamer-stabilizing ligands using theoretical binding, microcalorimetry, and nuclear magnetic resonance (NMR) line broadening techniques.

Authors:  S E McGraw; D J Craik; S Lindenbaum
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

3.  Peptide and metal ion-dependent association of isolated helix-loop-helix calcium binding domains: studies of thrombic fragments of calmodulin.

Authors:  R D Brokx; H J Vogel
Journal:  Protein Sci       Date:  2000-05       Impact factor: 6.725

4.  Elemental composition of secretory granules in pancreatic islets of Langerhans.

Authors:  M C Foster; R D Leapman; M X Li; I Atwater
Journal:  Biophys J       Date:  1993-02       Impact factor: 4.033

5.  Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.

Authors:  J C Hutton; E J Penn; M Peshavaria
Journal:  Biochem J       Date:  1983-02-15       Impact factor: 3.857

6.  Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.

Authors:  Nihar R Pandey; George Vardatsikos; Mohamad Z Mehdi; Ashok K Srivastava
Journal:  J Biol Inorg Chem       Date:  2009-11-28       Impact factor: 3.358

7.  Unique properties of Cd-binding peptides induced in fission yeast, Schizosaccharomyces pombe.

Authors:  Y Hayashi; C W Nakagawa; A Murasugi
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
  7 in total

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