Literature DB >> 700922

betah-endorphin: antidiuretic effects in rats.

L F Tseng, H H Loh, C H Li.   

Abstract

Human beta-endorphin (betah-EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is effective at doses (0.45 microgram) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of betah-endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of betah-endorphin.

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Year:  1978        PMID： 700922     DOI： 10.1111/j.1399-3011.1978.tb02882.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  3 in total

1.  Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation.

Authors:  Q J Pittman; J D Hatton; F E Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

2.  Antidiuretic effect of beta-endorphin and morphine in Brattleboro rats: development of tolerance and physical dependence after chronic morphine treatment.

Authors:  J P Huidobro-Toro
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

3.  beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.

Authors:  R A Houghten; R W Swann; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205
  3 in total

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