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Literature DB >> 7008783

Insulin stimulates synthesis of soluble proteins in isolated rat hepatocytes.

Abstract

The incorporation of [3H]leucine into soluble cellular protein was measured in isolated hepatocytes at extracellular leucine concentrations ranging from 0.15 to 20.0 mM. Insulin caused a 12--15% stimulation of [3H]leucine incorporation in the presence of high extracellular leucine concentrations. It is concluded that insulin causes a small but significant increase in the rate of hepatic protein synthesis.

Entities: Chemical Disease Species

Mesh：

Substances：
Insulin
Leucine

Year: 1980 PMID： 7008783 PMCID： PMC1162138 DOI： 10.1042/bj1900615

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

19 in total

1. Studies on the differential response to insulin on the stimulation of amino acid incorporation into protein in isolated hepatocytes containing different levels of glycogen.

Authors: S R Wagle; L Sampson
Journal: Biochem Biophys Res Commun Date: 1975-05-05 Impact factor: 3.575

2. Hormonal modulation of amino acid transport in rat hepatoma cells in tissue culture.

Authors: W L Risser; T D Gelehrter
Journal: J Biol Chem Date: 1973-02-25 Impact factor: 5.157

3. On the mechanism of glucose-6-phosphate dehydrogenase regulation in mouse liver. 3. The rate of enzyme synthesis and degradation.

Authors: A Hizi; G Yagil
Journal: Eur J Biochem Date: 1974-06-01

4. Fatty acid synthetase of developing brain and liver. Content, synthesis, and degradation during development.

Authors: J J Volpe; T O Lyles; D A Roncari; P R Vagelos
Journal: J Biol Chem Date: 1973-04-10 Impact factor: 5.157

5. Compartmentation of free valine and its relation to protein turnover in perfused rat liver.

Authors: G E Mortimore; K H Woodside; J E Henry
Journal: J Biol Chem Date: 1972-05-10 Impact factor: 5.157

6. Inhibition by insulin of valine turnover in liver. Evidence for a general control of proteolysis.

Authors: G E Mortimore; C E Mondon
Journal: J Biol Chem Date: 1970-05-10 Impact factor: 5.157

7. Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.

Authors: E A Khairallah; G E Mortimore
Journal: J Biol Chem Date: 1976-03-10 Impact factor: 5.157

Insulin stimulates synthesis of soluble proteins in isolated rat hepatocytes.

1. Studies on the differential response to insulin on the stimulation of amino acid incorporation into protein in isolated hepatocytes containing different levels of glycogen.

2. Hormonal modulation of amino acid transport in rat hepatoma cells in tissue culture.

3. On the mechanism of glucose-6-phosphate dehydrogenase regulation in mouse liver. 3. The rate of enzyme synthesis and degradation.

4. Fatty acid synthetase of developing brain and liver. Content, synthesis, and degradation during development.

5. Compartmentation of free valine and its relation to protein turnover in perfused rat liver.

6. Inhibition by insulin of valine turnover in liver. Evidence for a general control of proteolysis.

7. Assessment of protein turnover in perfused rat liver. Evidence for amino acid compartmentation from differential labeling of free and tRNA-gound valine.

8. Gluconeogenesis in the perfused rat liver.

9. Plasma protein synthesis by isolated rat hepatocytes.

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

1. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.

2. Metabolic effects of bacitracin in isolated rat hepatocytes.