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Literature DB >> 7007058

Randomized double-blind study of prophylactic methenamine hippurate treatment of patients with indwelling catheters.

A Norberg, B Norberg, U Parkhede, H Gippert, K Lundbeck.

Abstract

Catheterized patients with heavy bacteriuria and short catheter life received a short-course of antimicrobial therapy and then were allocated at random to double-blind treatment for 5 months with methenamine hippurate (MH), 1 g three times daily, or placebo 1 g 3 times daily. MH treatment reduced the number of catheter blockages and instances of spontaneous removal of the catheter, and doubled catheter life (p less than 0.001). It is suggested that the doubled catheter life was due to the reduced bacteriuria and lowering of urinary pH.

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Year: 1980 PMID： 7007058 DOI： 10.1007/bf00874662

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

11 in total

1. The generation of formaldehyde from methenamine. Effect of urinary flow and residual volume.

Authors: D M Musher; D P Griffith; Y Richie
Journal: Invest Urol Date: 1976-03

2. Generation of formaldehyde from methenamine: effect of pH and concentration, and antibacterial effect.

Authors: D M Musher; D P Griffith
Journal: Antimicrob Agents Chemother Date: 1974-12 Impact factor: 5.191

3. Effect of diuresis and frequent micturition on the bacterial content of infected urine: a measure of competence of intrinsic hydrokinetic clearance mechanisms.

Authors: W R Cattell; I K Fry; F I Spiro; J M Sardeson; M B Sutcliffe; F O'Grady
Journal: Br J Urol Date: 1970-06

4. A mathematical comparison of the effects of intermittent and continuous drainage of the bladder on its bacterial count.

Authors: J R Boen; C Markland; A S Cass
Journal: Invest Urol Date: 1969-01

5. The antimicrobial activity of urine of paraplegic patients receiving methenamine mandelate.

Authors: J W Pearman; G J Peterson; J B Nash
Journal: Invest Urol Date: 1978-09

6. Effect of short-term high-dose treatment with methenamine hippurate on urinary infection in geriatric patients with an indwelling catheter. IV. Clinical evaluation.

Authors: B Norberg; A Norberg; U Parkhede; H Gippert
Journal: Eur J Clin Pharmacol Date: 1979-06-12 Impact factor: 2.953

7. Lack of effect of methenamine in suppression of, or prophylaxis against, chronic urinary infection.

Authors: B Vainrub; D M Musher
Journal: Antimicrob Agents Chemother Date: 1977-11 Impact factor: 5.191

8. The voiding vesical defense mechanism: the mathematical effect of residual urine, voiding interval and volume on bacteriuria.

Authors: F Hinman; C E Cox
Journal: J Urol Date: 1966-10 Impact factor: 7.450