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Literature DB >> 7006876

Identification of biliary antigens in circulating immune complexes in primary biliary cirrhosis.

P Amoroso, D Vergani, B M Wojcicka, I G McFarlane, A L Eddleston, D E Tee, R Williams.

Abstract

The presence of biliary tract antigens in circulating immune complexes from patients with primary biliary cirrhosis (PBC) was investigated. Concentrations of immune complexes in PBC sera, measured by the Raji cell immunoassay, ranged from 58 to greater than 1,000 microgram/ml, but did not correlate with disease activity. Immunofluorescent staining of complexes bound to Raji cells was carried out with guinea-pig antiserum raised against biliary tract antigens. Positive staining reactions were observed with complexes obtained from PBC patients, but not with those obtained from patients with systemic lupus erythematosus or rheumatoid arthritis, indicating that in PBC antigenic components associated with the biliary tract are contained within the complexes.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1980 PMID： 7006876 PMCID： PMC1537061

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

7 in total

1. Circulating IgG complexes in primary biliary cirrhosis. A serial study in forty patients followed for two years.

Authors: R C Gupta; E R Dickson; F C McDuffie; A H Baggenstoss
Journal: Clin Exp Immunol Date: 1978-10 Impact factor: 4.330

2. Immune complexes in acute and chronic liver disease.

Authors: H C Thomas; D De Villiers; B Potter; H Hodgson; S Jain; D P Jewell; S Sherlock
Journal: Clin Exp Immunol Date: 1978-02 Impact factor: 4.330

3. A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes.

Authors: D Kingston; L E Glynn
Journal: Immunology Date: 1971-12 Impact factor: 7.397

4. Circulating immune complexes and complement activation in primary biliary cirrhosis.

Authors: J R Wands; J L Dienstag; A K Bhan; E R Feller; K J Isselbacher
Journal: N Engl J Med Date: 1978-02-02 Impact factor: 91.245

5. The Raji cell radioimmune assay for detecting immune complexes in human sera.

Authors: A N Theofilopoulos; C B Wilson; F J Dixon
Journal: J Clin Invest Date: 1976-01 Impact factor: 14.808

6. Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases.

Authors: I G McFarlane; B M Wojcicka; D C Tsantoulas; B C Portmann; A L Eddleston; R Williams
Journal: Gastroenterology Date: 1979-06 Impact factor: 22.682

7. Is primary biliary cirrhosis an immune complex disease?

Authors: H C Thomas; B J Potter; S Sherlock
Journal: Lancet Date: 1977-12-17 Impact factor: 79.321

7 in total

Review 1. Immunological abnormalities and hepatotropic viral infections.

Authors: I G McFarlane
Journal: Clin Exp Immunol Date: 1992-03 Impact factor: 4.330

Review 2. Primary biliary cirrhosis.

Authors: J Neuberger; M Lombard; R Galbraith
Journal: Gut Date: 1991-09 Impact factor: 23.059

7. Investigation of immune complexes formed by mitochondrial antigens containing a new lipoylated site in sera of primary biliary cholangitis patients.

Authors: N Aibara; K Ohyama; M Nakamura; H Nakamura; M Tamai; N Kishikawa; A Kawakami; K Tsukamoto; M Nakashima; N Kuroda
Journal: Clin Exp Immunol Date: 2021-03-22 Impact factor: 5.732

7 in total

Identification of biliary antigens in circulating immune complexes in primary biliary cirrhosis.

1. Circulating IgG complexes in primary biliary cirrhosis. A serial study in forty patients followed for two years.

2. Immune complexes in acute and chronic liver disease.

3. A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes.

4. Circulating immune complexes and complement activation in primary biliary cirrhosis.

5. The Raji cell radioimmune assay for detecting immune complexes in human sera.

6. Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases.

7. Is primary biliary cirrhosis an immune complex disease?

Review 1. Immunological abnormalities and hepatotropic viral infections.

Review 2. Primary biliary cirrhosis.

Review 3. Recent developments in primary biliary cirrhosis: etiology and treatment.

4. Circulating immune complexes in Indian childhood cirrhosis.

5. Localisation of immunoglobulin on the liver cell surface in primary biliary cirrhosis.

6. Circulating immune complexes in primary biliary cirrhosis: interactions with lymphoid cells.

7. Investigation of immune complexes formed by mitochondrial antigens containing a new lipoylated site in sera of primary biliary cholangitis patients.