The relationship of gastric acid secretion to plasma glucose in five men.

Twelve-hour basal gastric acid collection (no. = 113) and insulin-stimulated acid studies (no. = 47) were obtained in five healthy male volunteers. Basal collections were obtained during infusion with intravenous saline, 5% glucose, or 15% glucose solutions. Various insulin dosages were used for the insulin studies. Thus, for each subject a hyperglycemic to hypoglycemic plasma glucose range was produced which could be related to acid output. In the normoglycemic range (110 to 57 mg/100 ml) a graded acid increase was noted in association with a graded reduction in plasma glucose. This suggests that physiological variations in plasma glucose influence acid secretion in man.