Literature DB >> 7002832

Efficacy and side effects of chloral hydrate and tryptophan as sleeping aids in psychogeriatric patients.

M Linnoila, M Viukari, A Numminen, J Auvinen.   

Abstract

The effects of placebo, L-tryptophan 3 g, and chloral hydrate 500 mg on sleep were studied in 19 nonpsychotic, mildly demented, geriatric inpatients. Only chloral hydrate was more effective in inducing and maintaining sleep than placebo. Neither chloral hydrate not L-tryptophan had any significant side effects, but withdrawal of chloral hydrate was associated with insomnia.

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Year:  1980        PMID: 7002832     DOI: 10.1159/000468423

Source DB:  PubMed          Journal:  Int Pharmacopsychiatry        ISSN: 0020-8272


  4 in total

1.  Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects.

Authors:  R D Levitan; J H Shen; R Jindal; H S Driver; S H Kennedy; C M Shapiro
Journal:  J Psychiatry Neurosci       Date:  2000-09       Impact factor: 6.186

2.  Evaluation of L-tryptophan for treatment of insomnia: a review.

Authors:  D Schneider-Helmert; C L Spinweber
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

Review 3.  Pharmacotherapies for sleep disturbances in dementia.

Authors:  Jenny McCleery; Daniel A Cohen; Ann L Sharpley
Journal:  Cochrane Database Syst Rev       Date:  2016-11-16

4.  Pharmacotherapies for sleep disturbances in dementia.

Authors:  Jenny McCleery; Ann L Sharpley
Journal:  Cochrane Database Syst Rev       Date:  2020-11-15
  4 in total

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