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Literature DB >> 7001334

Intrauterine detection of cystic fibrosis.

Abstract

Thirteen pregnancies of obligate heterozygotes of cystic fibrosis have been prospectively monitored utilizing quantitative and qualitative measurements of methylumbelliferylguanidinobenzoate (MUGB) reactive proteases in amniotic fluid. In each case the diagnosis was accurately ascertained in midtrimester and confirmed after delivery. The measurement of MUGB reactivity in midtrimester amniotic fluid by three different procedures, quantitative analysis, polyacrylamide isoelectric focusing, and column filtration appears to provide a practical and reliable approach for the intrauterine detection of cystic fibrosis.

Entities: Chemical Disease

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Year: 1980 PMID： 7001334

Source DB: PubMed Journal: Pediatrics ISSN： 0031-4005 Impact factor: 7.124

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Cited

6 in total

1. Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis.

Authors: A Boué; F Muller; C Nezelof; J F Oury; F Duchatel; Y Dumez; M C Aubry; J Boué
Journal: Hum Genet Date: 1986-11 Impact factor: 4.132

2. Analysis of fetal intestinal enzymes in amniotic fluid for the prenatal diagnosis of cystic fibrosis.

Authors: R A Mulivor; D Cook; F Muller; A Boué; F Gilbert; M Mennuti; E Pergament; M Potier; H Nadler; H Punnett
Journal: Am J Hum Genet Date: 1987-02 Impact factor: 11.025

3. Prenatal diagnosis of cystic fibrosis: false negative result with the 4-methylumbelliferyl-p-guanidinobenzoate assay for proteases in amniotic fluid.

Authors: J R Green; M J Lentze; E Rossi; D Sidiropoulos; G Schubiger
Journal: Eur J Pediatr Date: 1982-09 Impact factor: 3.183

Intrauterine detection of cystic fibrosis.

1. Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis.

2. Analysis of fetal intestinal enzymes in amniotic fluid for the prenatal diagnosis of cystic fibrosis.

3. Prenatal diagnosis of cystic fibrosis: false negative result with the 4-methylumbelliferyl-p-guanidinobenzoate assay for proteases in amniotic fluid.

4. Screening for cystic fibrosis.

5. Intestinal obstruction and cystic fibrosis: antenatal ultrasound appearance.

6. Prenatal diagnosis of cystic fibrosis by assay of amniotic fluid microvillar enzymes.