Literature DB >> 700022

Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry.

M H Bickel, J Römer.   

Abstract

The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The differential spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.

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Year:  1978        PMID: 700022     DOI: 10.1007/bf01915339

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  7 in total

1.  Binding of basic and acidic drugs to rat tissue subcellular fractions.

Authors:  M H Bickel; J W Steele
Journal:  Chem Biol Interact       Date:  1974-03       Impact factor: 5.192

2.  Micellar properties of drugs: determination of molecular weight, size, and molecular interactions of drug micelles using the analytical ultracentrifuge.

Authors:  J Kirschbaum
Journal:  J Pharm Sci       Date:  1974-06       Impact factor: 3.534

3.  Micellar properties of drugs: micellar and nonmicellar patterns of self-association of hydrophobic solutes of different molecular structures--monomer fraction, availability, and misuses of micellar hypothesis.

Authors:  P Mukerjee
Journal:  J Pharm Sci       Date:  1974-06       Impact factor: 3.534

4.  Micellar properties of drugs: properties of micellar aggregates of phenothiazines and their aqueous solutions.

Authors:  D Attwood; A T Florence; J M Gillan
Journal:  J Pharm Sci       Date:  1974-06       Impact factor: 3.534

5.  Examination of phenothiazine-albumin interaction by ultraviolet difference spectrophotometry.

Authors:  P C Huang; S Gabay
Journal:  Biochem Pharmacol       Date:  1974-03-01       Impact factor: 5.858

6.  Membrane lipids as intracellular binders of chlorpromazine and related drugs.

Authors:  C D Francesco; M H Bickel
Journal:  Chem Biol Interact       Date:  1977-03       Impact factor: 5.192

7.  Characterization of interactions of phenothiazines and related drugs with lipids by UV-spectrophotometry.

Authors:  M H Bickel; H G Weder
Journal:  Psychopharmacol Commun       Date:  1976
  7 in total

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