Literature DB >> 7000132

Focal mesangial proliferative glomerulonephritis in the rat caused by Habu venom: the effect of antiplatelet agents.

V Cattell, A Mehotra.   

Abstract

The effects of the antiplatelet agents aspirin (ASA), dipyridamole (DP) and prostacyclin (PGI2) on glomerulonephritis following Habu snake venom have been investigated. ASA greatly increases glomerular damage and PGI2 inhibits glomerular damage. DP suppresses glomerular proliferation. The results extend previous studies on platelet activity in this model and provide evidence that (1) glomerular injury involves a platelet/endothelial reaction and (2) glomerular proliferation is affected by an antiplatelet drug.

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Year:  1980        PMID： 7000132      PMCID： PMC2041587     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  16 in total

1.  The platelet as a mediator of tissue damage in immune complex glomerulonephritis.

Authors:  W F Clark; M Friesen; A L Linton; R M Lindsay
Journal:  Clin Nephrol       Date:  1976-07       Impact factor: 0.975

2.  Focal mesangial proliferative glomerulonephritis in the rat caused by habu snake venom. A morphologic study.

Authors:  V Cattell; J W Bradfield
Journal:  Am J Pathol       Date:  1977-06       Impact factor: 4.307

3.  Action of Trimeresurus flavoviridis venom and the partially purified hemorrhagic principles on animal cells cultivated in vitro.

Authors:  H Yoshikura; H Ogawa; A Osaka; T Omori-Sato
Journal:  Toxicon       Date:  1966-11       Impact factor: 3.033

4.  Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

Authors:  L A Harker; R Ross; S J Slichter; C R Scott
Journal:  J Clin Invest       Date:  1976-09       Impact factor: 14.808

5.  Thrombogenic effect of high-dose aspirin in rabbits. Relationship to inhibition of vessel wall synthesis of prostaglandin I2-like activity.

Authors:  J G Kelton; J Hirsh; C J Carter; M R Buchanan
Journal:  J Clin Invest       Date:  1978-10       Impact factor: 14.808

6.  Prostacyclin-like activity in rat vascular tissues. Fast, long-lasting inhibition by treatment with lysine acetylsalicylate.

Authors:  S Villa; G de Gaetano
Journal:  Prostaglandins       Date:  1977

7.  Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy.

Authors:  R Korbut; S Moncada
Journal:  Thromb Res       Date:  1978-09       Impact factor: 3.944

8.  Prostacyclin effects on renal hemodynamic and excretory functions in the rat.

Authors:  P G Baer; M L Kauker; J C McGiff
Journal:  J Pharmacol Exp Ther       Date:  1979-02       Impact factor: 4.030

9.  Prostacyclin can replace heparin in haemodialysis in dogs.

Authors:  H F Woods; G Ash; M J Weston; S Bunting; S Moncada; J R Vane
Journal:  Lancet       Date:  1978-11-18       Impact factor: 79.321

10.  Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat.

Authors:  A W Clowes; M J Karnovsky
Journal:  Lab Invest       Date:  1977-04       Impact factor: 5.662
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  2 in total

1.  Platelet-complement interactions in mesangial proliferative nephritis in the rat.

Authors:  R J Johnson; P Pritzl; H Iida; C E Alpers
Journal:  Am J Pathol       Date:  1991-02       Impact factor: 4.307

2.  Heparin inhibits mesangial cell proliferation in habu-venom-induced glomerular injury.

Authors:  A K Coffey; M J Karnovsky
Journal:  Am J Pathol       Date:  1985-08       Impact factor: 4.307
  2 in total

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