Literature DB >> 6998717

Binding of antimalarial drugs to hemozoin from Plasmodium berghei.

A Jearnpipatkul, P Govitrapong, Y Yuthavong, P Wilairat, B Panijpan.   

Abstract

Chloroquine, quinacrine and mefloquine bind to Plasmodium berghei hemozoin, hemin, hemi, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.

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Year:  1980        PMID： 6998717     DOI： 10.1007/bf01965970

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in Plasmodium berghei.

Authors:  D C Warhurst; S C Thomas
Journal:  Biochem Pharmacol       Date:  1975-11-15       Impact factor: 5.858

2.  Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA.

Authors:  M W Davidson; B G Griggs; D W Boykin; W D Wilson
Journal:  Nature       Date:  1975-04-17       Impact factor: 49.962

3.  ANTAGONISM OF THE ANTIMALARIAL ACTION OF CHLOROQUINE BY FERRIHEMATE AND AN HYPOTHESIS FOR THE MECHANISM OF CHLOROQUINE RESISTANCE.

Authors:  F W SCHUELER; W F CANTRELL
Journal:  J Pharmacol Exp Ther       Date:  1964-03       Impact factor: 4.030

4.  Hemoglobin synthesis in rabbit reticulocytes in vitro.

Authors:  J KRUH; H BORSOOK
Journal:  J Biol Chem       Date:  1956-06       Impact factor: 5.157

5.  Current concepts in parasitology. Malaria.

Authors:  W Peters
Journal:  N Engl J Med       Date:  1977-12-08       Impact factor: 91.245

6.  Plasmodium lophurae: composition and properties of hemozoin, the malarial pigment.

Authors:  K A Yamada; I W Sherman
Journal:  Exp Parasitol       Date:  1979-08       Impact factor: 2.011

7.  Location of chloroquine binding sites in Plasmodium berghei.

Authors:  P A Kramer; J E Matusik
Journal:  Biochem Pharmacol       Date:  1971-07       Impact factor: 5.858

8.  Studies concerning the mechanism of action of antimalarial drugs. II. Inhibition of the incorporation of adenosine-5'-monophosphate- 3 H into nucleic acids of erythrocyte-free malarial parasites.

Authors:  C H Lantz; K Van Dyke
Journal:  Biochem Pharmacol       Date:  1971-06       Impact factor: 5.858

9.  Chloroquine resistance in malaria: accessibility of drug receptors to mefloquine.

Authors:  C D Fitch; R L Chan; R Chevli
Journal:  Antimicrob Agents Chemother       Date:  1979-02       Impact factor: 5.191

10.  Chloroquine resistance in malaria: a deficiency of chloroquine binding.

Authors:  C D Fitch
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205
  10 in total
  2 in total

Review 1.  Resistance of Plasmodium falciparum.

Authors:  E B Doberstyn
Journal:  Experientia       Date:  1984-12-15

2.  Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Authors:  Vishal Patel; Michael Booker; Martin Kramer; Leila Ross; Cassandra A Celatka; Leah M Kennedy; Jeffrey D Dvorin; Manoj T Duraisingh; Piotr Sliz; Dyann F Wirth; Jon Clardy
Journal:  J Biol Chem       Date:  2008-10-08       Impact factor: 5.157
  2 in total

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