Literature DB >> 6997994

Autoantibodies against axonal neurofilaments in patients with Kuru and Creutzfeldt-Jakob disease.

J Sotelo, C J Gibbs, D C Gajdusek.   

Abstract

The serums of some patients with subacute spongiform encephalopathies contain an autoantibody in higher titer against a normal fibrillar protein within the axon of mature central neurons in culture. The morphological features of this neurofilament, as demonstrated by immunofluorescence and immunoperoxidase staining, and the partial characterization of the antibody are described. The detection of this hetero-specific autoantibody is the first evidence of an immune reaction in the spongiform encephalopathies.

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Year:  1980        PMID： 6997994     DOI： 10.1126/science.6997994

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Antibodies to T- and L-isoforms of the cytoskeletal protein, fimbrin, in patients with systemic lupus erythematosus.

Authors:  E C De Mendonca Neto; A Kumar; N A Shadick; A M Michon; P Matsudaira; R B Eaton; P Kumar; P H Schur
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

2.  Detection of anti-glutamate receptor ε2 and anti-N-methyl-D: -aspartate receptor antibodies in a patient with sporadic Creutzfeldt-Jakob disease.

Authors:  Koji Fujita; Tatsuhiko Yuasa; Yukitoshi Takahashi; Keiko Tanaka; Shuji Hashiguchi; Katsuhito Adachi; Yuishin Izumi; Ryuji Kaji
Journal:  J Neurol       Date:  2011-11-05       Impact factor: 4.849

Review 3.  Molecular mimicry as a mechanism for virus-induced autoimmunity.

Authors:  R S Fujinami; M B Oldstone
Journal:  Immunol Res       Date:  1989       Impact factor: 2.829

4.  Antibodies to neurofilament protein in retinitis pigmentosa.

Authors:  G M Galbraith; D Emerson; H H Fudenberg; C J Gibbs; D C Gajdusek
Journal:  J Clin Invest       Date:  1986-10       Impact factor: 14.808

5.  Serum antibodies against central nervous system proteins in human demyelinating disease.

Authors:  J Newcombe; S Gahan; M L Cuzner
Journal:  Clin Exp Immunol       Date:  1985-02       Impact factor: 4.330

6.  Presence of voltage-gated potassium channel complex antibody in a case of genetic prion disease.

Authors:  Adham Jammoul; Richard J Lederman; Jinny Tavee; Yuebing Li
Journal:  BMJ Case Rep       Date:  2014-06-05

7.  Anti-CNS antibodies in neurological and psychiatric disorders.

Authors:  A V Plioplys; J Thibault; J P Bouchard; C Cockburn; R Hawkes
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-11       Impact factor: 10.154

8.  The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.

Authors:  B H Toh; C J Gibbs; D C Gajdusek; D D Tuthill; D Dahl
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

9.  Heterogeneic autoantibody against neurofilament protein in the sera of animals with experimental kuru and Creutzfeldt-Jakob disease and natural scrapie infection.

Authors:  T Aoki; C J Gibbs; J Sotelo; D C Gajdusek
Journal:  Infect Immun       Date:  1982-10       Impact factor: 3.441

10.  Human upper epidermal cytoplasmic antibodies are directed against keratin intermediate filament proteins.

Authors:  H Hintner; P M Steinert; T J Lawley
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808
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