| Literature DB >> 6997739 |
T Moen, D Albrechtsen, A Flatmark, A Jakobsen, J Jervell, S Halvorsen, B G Solheim, E Thorsby.
Abstract
To investigate the influence of matching for HLA-DR antigens in renal transplantation, we assessed the outcome of 170 prospectively HLA-typed cadaveric kidney transplantations performed since 1977 in one center. We found a beneficial effect on graft survival of HLA-DR compatibility between donor and recipient (P < 0.05). A possible effect of matching for the HLA-A and B antigens could be seen only in the HLA-DR-mismatched combinations. Pretransplantation blood transfusions were associated with increased graft survival only in patients receiving HLA-DR mismatched transplants (P < 0.02). We conclude that major emphasis should be placed on obtaining HLA-DR compatibility renal transplantation. (N Engl J Med. 1980; 303:850-4).Entities:
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Year: 1980 PMID： 6997739 DOI： 10.1056/NEJM198010093031504
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245