Literature DB >> 6996061

Immunochemical demonstration of immunoreactive insulin in human breast cancer.

A Castro, J Ziegels-Weissman, P Buschbaum, W Voigt, A Morales, M Nadji.   

Abstract

The immunoreactive insulin contents of the cytosol extracts of 57 human mammary carcinomas were measured by specific radioimmunoassay. All of these extracts contained measurable insulin (detection limit 1.3 ng/g tumor). In some cases (23) the levels were quite greater than the normal human serum levels. Immunoperoxidase technique revealed the presence of immunoreactive insulin within the cytoplasm of tumor cells in 6 cases.

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Year:  1980        PMID: 6996061

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN: 0034-5164


  3 in total

1.  Intracellular insulin in human tumors: examples and implications.

Authors:  Razvan T Radulescu
Journal:  Diabetol Metab Syndr       Date:  2011-04-01       Impact factor: 3.320

2.  Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.

Authors:  Gregor Weirich; Karin Mengele; Christina Yfanti; Apostolos Gkazepis; Daniela Hellmann; Anita Welk; Cecylia Giersig; Wen-Liang Kuo; Marsha Rich Rosner; Wei-Jen Tang; Manfred Schmitt
Journal:  Biol Chem       Date:  2008-11       Impact factor: 3.915

3.  Corticotropin-releasing hormone, luteinizing hormone-releasing hormone, growth hormone-releasing hormone, and somatostatin-like immunoreactivities in biopsies from breast cancer patients.

Authors:  D R Ciocca; L A Puy; L C Fasoli; O Tello; J C Aznar; F E Gago; S I Papa; R Sonego
Journal:  Breast Cancer Res Treat       Date:  1990-05       Impact factor: 4.872

  3 in total

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