Literature DB >> 6995551

Clonal nature of the immune response. II. The effect of immunization on clonal commitment.

D E Briles, J M Davie.   

Abstract

An inbred strain can produce several hundred different anti-group A carbohydrate (GAC) antibodies, as analyzed by isoelectric focusing. However, each individual mouse produces the bulk of its anti-GAC antibody as only one or two different spectrotypes, which appear to be randomly chosen. By using adoptive transfer techniques, we have observed that clonal commitment occurs very early in immunization, sometimes even before immunization, and thus does not result from competition among B cells for antigen. X

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Year:  1980        PMID： 6995551      PMCID： PMC2185905          DOI： 10.1084/jem.152.1.151

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  21 in total

1.  Individual Antigenic Specificity of Isolated Antibodies.

Authors:  H G Kunkel; M Mannik; R C Williams
Journal:  Science       Date:  1963-06-14       Impact factor: 47.728

2.  Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice.

Authors:  K Eichmann
Journal:  Eur J Immunol       Date:  1972-08       Impact factor: 5.532

3.  Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.

Authors:  J Urbain; M Wikler; J D Franssen; C Collignon
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

4.  Detection of isoelectric focused antibody by autoradiography and hemolysis of antigen-coated erythrocytes. A comparison of methods.

Authors:  D E Briles; J M Davie
Journal:  J Immunol Methods       Date:  1975-10       Impact factor: 2.303

5.  Inheritance of antibody specificity. IV. Control of related molecular species by one VH gene.

Authors:  O Mäkelä; K Karjalainen
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

6.  Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.

Authors:  P A Cazenave
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

7.  Mouse antibodies to group A streptococcal carbohydrate; use of idiotypy to detect inbred strain specificity and to monitor spleen cell transfer in syngenetic mice.

Authors:  D E Briles; R M Krause
Journal:  J Immunol       Date:  1972-12       Impact factor: 5.422

8.  Clonal dominance. I. Restricted nature of the IgM antibody response to group A streptococcal carbohydrate in mice.

Authors:  D E Briles; J M Davie
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

9.  Antibody-specific immunoregulation.

Authors:  S K Pierce; N R Klinman
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307

10.  Complete inhibition of the expression of an idiotype by a mechanism of B-cell dominance.

Authors:  B M Eig; S T Ju; A Nisonoff
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307
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  6 in total

1.  Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.

Authors:  C T Lutz; T L Bartholow; N S Greenspan; R J Fulton; W J Monafo; R M Perlmutter; H V Huang; J M Davie
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307

2.  Construction of an extended three-dimensional idiotope map by electron microscopic analysis of idiotope-anti-idiotope complexes.

Authors:  K H Roux; W J Monafo; J M Davie; N S Greenspan
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

Review 3.  Use of licensed vaccines for active immunization of the immunocompromised host.

Authors:  L A Pirofski; A Casadevall
Journal:  Clin Microbiol Rev       Date:  1998-01       Impact factor: 26.132

4.  Analysis of human anti-diphtheria antibodies by isoelectric focusing: evidence for restricted clonal heterogeneity of anti-fragment A antibodies.

Authors:  C D Morrow; E M Macy; R H Stevens
Journal:  Infect Immun       Date:  1981-03       Impact factor: 3.441

5.  The B cell repertoire revealed by major histocompatibility complex-specific helper T cells. I. Frequencies of a genetically defined V region marker among mitogen- and T helper cell-reactive B lymphocytes in normal and immunized mice.

Authors:  D Primi; P A Cazenave
Journal:  J Exp Med       Date:  1984-04-01       Impact factor: 14.307

6.  Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae.

Authors:  L S McDaniel; G Scott; J F Kearney; D E Briles
Journal:  J Exp Med       Date:  1984-08-01       Impact factor: 14.307
  6 in total

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