Mechanism of leukocyte locomotion in hemophilia.

In order to study a relationship between leukocyte locomotion and hemophilia, three assays to investigate cell motility were performed: Investigations were carried out, firstly, on the leukocyte locomotion (LL), secondly, on the activability of sera by zymosan, and thirdly, on the influence of sera upon LL. 17 patients with hemophilia and 16 healthy control persons were included in the study. While LL of patients and controls did not differ significantly with either cytotaxin, zymosan activated serum of patients or controls, or casein, sera of patients were significantly less activatable (p< 0.0001) than control sera. Locomotion of control leukocytes was significantly inhibited (p<0.002) by sera of hemophiliacs.