Literature DB >> 6993939

Mutagenic potency of haloacroleins and related compounds.

J D Rosen, Y Segall, J E Casida.   

Abstract

2-Chloroacrolein, the ultimate mutagen, formed on metabolism of the carcinogenc herbicides, diallate and sulfallate, and its 2-bromo-, 2,3-dichloro- and 2,3,3-trichloro- analogs are much more potent mutagens in the Ames Salmonella typhimurium strain TA1U0 assay than any other aldehydes examined previously or in this study. Polymer formation on reaction of deoxyadenosine with the difunctional 2-chloroacrolein probably involves crosslinking via Schiff base formation at the carbonyl group and Michael addition at the doubts bond.

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Year:  1980        PMID： 6993939     DOI： 10.1016/0165-1218(80)90090-7

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  3 in total

1.  Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Authors:  Chunyong Ding; Yusong Zhang; Haijun Chen; Zhengduo Yang; Christopher Wild; Na Ye; Corbin D Ester; Ailian Xiong; Mark A White; Qiang Shen; Jia Zhou
Journal:  J Med Chem       Date:  2013-10-31       Impact factor: 7.446

2.  1,N2-cyclic deoxyguanosine adducts and guanine adducts of 2-haloacroleins. Isolation, characterization, isomerization and stability.

Authors:  E Eder; C Hoffman
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

3.  Degradation of 2-chloroallylalcohol by a Pseudomonas sp.

Authors:  J J van der Waarde; R Kok; D B Janssen
Journal:  Appl Environ Microbiol       Date:  1993-02       Impact factor: 4.792
  3 in total

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