Literature DB >> 6993886

The extra nuclear control of mitosis & cell function. A theory of cellular organisation.

J A Holt.   

Abstract

There is evidence to suggest that the extra nuclear cell constituents are the part of the cell which contains all the biochemical mechanisms responsible for implementing all cell functions. These functions include control of cell division, growth, response to injury, replacement of effete cells, maintenance of anatomical and spatial cellular relations and specific cellular function and structure. The energy to perform these functions is derived from the aerobic metabolism of glucose. The energy required for nuclear division appears to be wholly or partly derived from the anaerobic metabolism of glucose. Ethyl alcohol interferes with the aerobic metabolic pathways and thus disrupts or diminishes all aerobically activated cell functions. The speed of all activities motivated by aerobic glycolysis can be increased by appropriate electrical stimulations delivered from any of a range of electromagnetic radiation frequencies tested. In addition to the stimulant effect on aerobic metabolic processes, 434 MHz can stimulate the anaerobic glucose metabolism of cancer with consequent stimulation of cancer growth rate. 434 MHz appears to deliver energy to the anaerobic cancer metabolism by causing a resonance phenomenon amongst one or more of the substrates which comprise the first few stages of glycolysis. This phenomenon permits the selective delivery of electromagnetic radiation energy to cancer cells which, if sufficiently intense, causes injury to cancer cells without harm to the normal cells except when the latter are in the phase of anaerobic metabolism which occurs at some stage of the mitotic cycle. Streptokinase, ethanol and glucose analogues increase the lethal effects on cancers undergoing therapy with 434 MHz radiation and observations of such responses suggest a theoretical basis to explain the rare spontaneous remissions of human cancer. Cancer appears to protect its glucose supplies by elevating the blood glucose levels above normal and by some mechanism which reduces the effectiveness of the body's control of its fasting glucose level. The serum fibrinogen level rises when cancer involves the abdominal viscerae, particularly the liver. A raised serum fibrinogen level appears to be a direct indication that the liver must be included in the treatment regime if longer survival is desired. If the level cannot be corrected then death of that individual appears assured.

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Year:  1980        PMID: 6993886     DOI: 10.1016/0306-9877(80)90081-x

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  3 in total

1.  Hyperbaric oxygen therapy in acute trauma.

Authors:  J A Holt
Journal:  Ann R Coll Surg Engl       Date:  1980-07       Impact factor: 1.891

2.  Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model.

Authors:  Vladimir Bobek; Jiri Plachy; Daniela Pinterova; Katarina Kolostova; Michael Boubelik; Ping Jiang; Meng Yang; Robert M Hoffman
Journal:  Clin Exp Metastasis       Date:  2004       Impact factor: 5.150

3.  III. Cellular ultrastructures in situ as key to understanding tumor energy metabolism: biological significance of the Warburg effect.

Authors:  Halina Witkiewicz; Phil Oh; Jan E Schnitzer
Journal:  F1000Res       Date:  2013-01-10
  3 in total

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