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Literature DB >> 6993076

Cimetidine does not accelerate skin graft rejection in mice.

Abstract

The influence of cimetidine on skin graft rejection was studied in a well defined transplantation model of inbred mice. Four allogeneic transplantation combinations with increasing antigenic disparity and one xenograft combination were studied. Cimetidine (25 mg/kg body weight) was administered intraperitoneally at 8-hr intervals until rejection occurred. No differences in graft survival were observed between cimetidine-treated groups and saline-treated controls in any of the combinations studied.

Entities: Chemical Species

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Year: 1980 PMID： 6993076 PMCID： PMC1536940

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

18 in total

1. Properties of a subpopulation of T cells bearing histamine receptors.

Authors: M Plaut; L M Lichtenstein; C S Henney
Journal: J Clin Invest Date: 1975-04 Impact factor: 14.808

2. Antibody response and skin graft rejection in the nude mouse.

Authors: P G Gerlag; P J Capel; J H Berden; R A Koene
Journal: Transplant Proc Date: 1977-03 Impact factor: 1.066

3. Skin grafts in nude mice. 1. Allografts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL).

Authors: J Rygaard
Journal: Acta Pathol Microbiol Scand A Date: 1974-01

4. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection.

Authors: R J Corry; H J Winn; P S Russell
Journal: Transplantation Date: 1973-10 Impact factor: 4.939

Review 5. The non-H-2 histocompatibility loci and their antigens.

Authors: R J Graff; D W Bailey
Journal: Transplant Rev Date: 1973

6. Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.

Authors: M Plaut; L M Lichtenstein; E Gillespie; C S Henney
Journal: J Immunol Date: 1973-08 Impact factor: 5.422

Cimetidine does not accelerate skin graft rejection in mice.

1. Properties of a subpopulation of T cells bearing histamine receptors.

2. Antibody response and skin graft rejection in the nude mouse.

3. Skin grafts in nude mice. 1. Allografts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL).

4. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection.

Review 5. The non-H-2 histocompatibility loci and their antigens.

6. Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.

7. Unresponsiveness of nude mice to skin allografts.

8. Immunological and other laboratory studies of patients receiving short-term cimetidine therapy.

9. Immunological studies after long-term H2-receptor-antagonist therapy.

10. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.

1. The effect of cimetidine on antibody synthesis in vitro and in vivo.

2. Peripheral blood T lymphocytes in patients with duodenal ulcers treated with cimetidine.