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Literature DB >> 6993069

Antitubulin antibody in healthy adults and patients with infectious mononucleosis and its relationship to smooth muscle antibody (SMA).

Abstract

Antibody to tubulin in man has been studied using a specific radioimmunoassay, affinity chromatography radioimmunoassay but markedly increased levels were noted in patients with infectious mononucleosis where the antibody was predominantly IgM in type. This finding was confirmed on fluorescence microscopy. Affinity chromatography purified antibody produced characteristic microtubular staining of fixed 3T3 cells, but in addition, produced weak staining of cryostat sections of rat tissue, similar in distribution to that of smooth muscle antibody. Our studies indicate that the IgM smooth muscle antibody found in infectious mononucleosis by IF techniques is at least in part due to an antitubulin antibody.

Entities: Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6993069 PMCID： PMC1538082

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

24 in total

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Journal: Clin Exp Immunol Date: 1974-06 Impact factor: 4.330

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Authors: M L Shelanski; F Gaskin; C R Cantor
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

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Journal: J Biol Chem Date: 1971-10-25 Impact factor: 5.157

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Authors: V Basson; A A Sharp
Journal: J Clin Pathol Date: 1969-05 Impact factor: 3.411

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Authors: E J Holborow; E H Hemsted; S V Mead
Journal: Br Med J Date: 1973-08-11

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Authors: G Gabbiani; G B Ryan; J P Lamelin; P Vassalli; G Majno; C A Bouvier; A Cruchaud; E F Lüscher
Journal: Am J Pathol Date: 1973-09 Impact factor: 4.307

17 in total

1. Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.

Authors: G Dighiero; P Lymberi; C Monot; N Abuaf
Journal: Clin Exp Immunol Date: 1990-10 Impact factor: 4.330

2. Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1.

Authors: J H Vaughan; J R Valbracht; M D Nguyen; H H Handley; R S Smith; K Patrick; G H Rhodes
Journal: J Clin Invest Date: 1995-03 Impact factor: 14.808

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Journal: Clin Exp Immunol Date: 1985-02 Impact factor: 4.330

4. Anti-tubulin-α-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations.

Authors: Xiaozhen Zhao; Yongjing Cheng; Yuzhou Gan; Rulin Jia; Lei Zhu; Xiaolin Sun
Journal: Clin Rheumatol Date: 2018-02-09 Impact factor: 2.980

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Authors: D Zauli; C Crespi; F B Bianchi; A Craxi; E Pisi
Journal: J Clin Pathol Date: 1986-08 Impact factor: 3.411

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Authors: F Bernier-Valentin; R Rabilloud; B Rousset
Journal: Clin Exp Immunol Date: 1988-02 Impact factor: 4.330

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Journal: J Clin Microbiol Date: 1984-11 Impact factor: 5.948