Literature DB >> 6992961

Short-lived mutagen in Salmonella produced by reaction of trichloroacetic acid and dimethyl sulphoxide.

E R Nestmann, I Chu, D J Kowbel, T I Matula.   

Abstract

A chemical reaction occurs when trichloroacetic acid (TCA) is dissolved in dimethyl sulphoxide (DMSO), with the production of a short-lived mutagenic derivative which was detected using the Salmonella/mammalian-microsome plate overlay assay. Other interactions between test chemicals and solvents are discussed. Choice of proper solvents in mutagenicity testing is emphasized.

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Year:  1980        PMID: 6992961     DOI: 10.1139/g80-006

Source DB:  PubMed          Journal:  Can J Genet Cytol        ISSN: 0008-4093


  2 in total

1.  An assessment of the teratogenicity in the rat and mutagenicity in Salmonella of mono-2-ethylhexyl phthalate.

Authors:  J A Ruddick; D C Villeneuve; I Chu; E Nestmann; D Miles
Journal:  Bull Environ Contam Toxicol       Date:  1981-08       Impact factor: 2.151

2.  Subacute toxicity and mutagenicity of cis-9,10-epoxystearic acid.

Authors:  I Chu; D C Villeneuve; E R Nestmann; G Douglas; G C Becking; R Lough; T I Matula
Journal:  Bull Environ Contam Toxicol       Date:  1980-09       Impact factor: 2.151

  2 in total

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