Literature DB >> 6991444

Reversible suppression of allo-antibody production by cyclosporin A.

S Denham, J M Styles, R K Barfoot, C J Dean.   

Abstract

Treatment of rats with 25 mg/kg/day of cyclosporin A suppressed their immune response to skin allografts. Withdrawal of cyclosporin A treatment led to complete recovery of specific immune responsiveness and the time taken for recovery was independent of the duration of treatment. Titration of the dose of cyclosporin A administered in vivo indicated that doses of 12 mg/kg/day or less were not fully immunosuppressive.

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Year:  1980        PMID： 6991444     DOI： 10.1159/000232548

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  4 in total

1.  Experimental cyclosporin A nephrotoxicity.

Authors:  P H Whiting; A W Thomson; J T Blair; J G Simpson
Journal:  Br J Exp Pathol       Date:  1982-02

Review 2.  Cyclosporine: immunology, toxicity and pharmacology in experimental animals.

Authors:  A W Thomson; P H Whiting; J G Simpson
Journal:  Agents Actions       Date:  1984-10

3.  Effect of cyclosporin A on the anti-leukaemia action associated with graft-versus-host disease.

Authors:  S Denham; S Attridge; R K Barfoot; P Alexander
Journal:  Br J Cancer       Date:  1983-06       Impact factor: 7.640

4.  Effect of cyclosporin A on the growth and spontaneous metastasis of syngeneic animal tumours.

Authors:  S A Eccles; S E Heckford; P Alexander
Journal:  Br J Cancer       Date:  1980-08       Impact factor: 7.640
  4 in total

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