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Literature DB >> 6991432

Effect of Treponema pallidum-infected testis supernatants on the cellular response of normal rabbit lymphocytes.

Abstract

This report presents evidence indicating that both Treponema pallidum and the T. pallidum-free supernatant from T. pallidum-infected rabbit testes exert an immunosuppressive effect on the spontaneous proliferation and mitogenic response of normal rabbit lymphocytes. This effect seemed to be on the level of clonal expansion since antigenic recognition and blastogenic factor production occurred in spite of the presence of the immunosuppressive substance(s). The implication of this finding for T. pallidum multiplication in rabbit testes is discussed.

Entities: Disease Species

Mesh：

Year: 1980 PMID： 6991432 PMCID： PMC550850 DOI： 10.1128/iai.27.3.846-850.1980

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

8 in total

1. Studies on the mechanism of action of cortisone in experimental syphilis.

Authors: T B TURNER; D H HOLLANDER
Journal: Am J Syph Gonorrhea Vener Dis Date: 1954-09

2. Hyaluronidase and experimental syphilis. III. Metachromasia in syphilitic orchitis and its relationship to hyaluronic acid.

Authors: V SCOTT; G J DAMMIN
Journal: Am J Syph Gonorrhea Vener Dis Date: 1950-11

3. Cortisone in experimental syphilis; a preliminary note.

Authors: T B TURNER; D H HOLLANDER
Journal: Bull Johns Hopkins Hosp Date: 1950-11

4. In vitro studies in reproductive immunology. 1. Suppression of cell-mediated immune response by human spermatozoa and fractions isolated from human seminal plasma.

Authors: Z H Marcus; J H Freisheim; J L Houk; J H Herman; E V Hess
Journal: Clin Immunol Immunopathol Date: 1978-03

5. In vitro cell response of Treponema pallidum-infected rabbits. III. Impairment in production of lymphocyte mitogenic factor.

Authors: V Wicher; K Wicher
Journal: Clin Exp Immunol Date: 1977-09 Impact factor: 4.330

2 in total

1. Studies of rabbit testes infected with Treponema pallidum. III. Immunosuppressive activity of infiltrating mononuclear cells.

Authors: V Wicher; K Wicher
Journal: Br J Vener Dis Date: 1984-02

2. Reappraisal of lymphocyte responsiveness to concanavalin A during experimental syphilis: evidence that glycosaminoglycans in the sera and tissues interfere ith active binding sites on the lectin and not with the lymphocytes.

Authors: R E Baughn; D M Musher
Journal: Infect Immun Date: 1982-02 Impact factor: 3.441